What's Wrong With My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice

Book Description

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse?

Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters:

"Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis.

"Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions.

The final chapter, "The Next Generation," examines new and emerging technologies.

Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Customer Reviews:

Valuable Book.......2002-11-19

"...this valuable book is currently the most complete overview of behavioral procedures available...it is a must have and a must read book..." (Genes, Brain, and Behavior, 2002)

Essential Book.......2001-07-24

"I would recommend that every behavioral scientist has at least two copies, one for their own use and one that will be on permanent loan to their students, post-doctoral students and colleagues in molecular biology." -- TRENDS in Pharmacological Sciences (Gerard R. Dawson, Merck Sharp & Dohme Research Laboratories)

Expert Review.......2001-07-24

"[T]his volume succeeds as a useful introduction to the realm of behavioral phenotyping for those interested in creating or using the large and increasing number of promising targeted mutant mice." -- TRENDS in Neurosciences (John K. Belknap, Oregon Health Sciences University)

Review.......2000-06-15

It is a much prized addition... and fulfills a heretofore unmet need for a comprehensive sourcebook of mutant mouse literature and procedures. In addition to its reference utility, Dr. Crawley's text can exert a valuable influence on the future of transgenic and knockout mouse research by standardizing behavioral phenotyping methods according to the present state-of-the-art. --Stephen C. Heinrichs, Ph.D., Boston College

an excellent resource.......2000-06-08

Very timely given the increasingly recognized importance of providing behavioral phenotypes of mutant mice. I would recommend the book with enthusiasm. --Eric Nestler, Yale University School of Medicine

Models of My Life (Sloan Foundation Science Series)

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The Satisficing Animal in Our Bounded Rationality
Another Great Reference
Twentieth-Century Polymath
Renaissance Man of the 20th Century
Learn the Why and How of a Distinguished Life

Models of My Life (Sloan Foundation Science Series)
Herbert A. Simon
Manufacturer: Basic Books
ProductGroup: Book
Binding: Paperback

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ASIN: 046504641X

Book Description

In this candid and witty autobiography, Nobel laureate Herbert A. Simon looks at his distinguished and varied career, continually asking himself whether (and how) what he learned as a scientist helps to explain other aspects of his life.

A brilliant polymath in an age of increasing specialization, Simon is one of those rare scholars whose work defines fields of inquiry. Crossing disciplinary lines in half a dozen fields, Simon's story encompasses an explosion in the information sciences, the transformation of psychology by the information-processing paradigm, and the use of computer simulation for modeling the behavior of highly complex systems.

Simon's theory of bounded rationality led to a Nobel Prize in economics, and his work on building machines that think -- based on the notion that human intelligence is the rule-governed manipulation of symbols -- laid conceptual foundations for the new cognitive science. Subsequently, contrasting metaphors of the maze (Simon's view) and of the mind (neural nets) have dominated the artificial intelligence debate.

There is also a warm account of his successful marriage and of an unconsummated love affair, letters to his children, columns, a short story, and political and personal intrigue in academe.

Customer Reviews:

The Satisficing Animal in Our Bounded Rationality.......2007-07-11

Satisficing as in searching for "good enough" actions rather than the optimal ones is one of the many contributions Herbert Simon is most famous for, in addition to being one of the parents of Artificial Intelligence. Whether the topic is management decision making, economics, traveling, teaching, or computer programs, this Renaissance Man had a life that many or most would envy.

Herbert Simon is a true example to exemplify the benefits of multi-discipline efforts as one subject does not always know the answers. If anyone is interested in building their own latticework of mental models then the life of Mr. Simon is one to emulate. As this is not your average biography, expect to be challenged as the reading may take you to subjects that you are unaware of or have been exposed to. However, this is what makes the experience worth the trip as my many notes and earmarks attest to.

As his life was about scientific discovery to quote, "I have sketched the theory of scientific discovery to which my study of these problems has led me. It is not a theory of global rationality but one of human limited computation in the face of complexity". Yes, we live in an evermore complex world and I am glade I have some of Mr. Simon's mental models to guide me through it.

Another Great Reference.......2007-01-05

If you are a graduate student of management, this is must for you. Simon is an icon in the field of decision-making. Much of his work has inspired contiuned research in the field of decision-making. An extraordinary man with extraordinary vision.

Twentieth-Century Polymath.......2005-05-21

This intellectual autobiography is not just a chronology of the particulars of a great intellectual life. It is a wonderful opportunity to obtain a coherent overview of the views and contributions of one of the twentieth century's great thinkers. Simon - political scientist with his Ph.D. from University of Chicago, founder of the new and emerging area of artificial intelligence, cognitive psychologist, Cargegie-Mellon faculty member, Nobel laureate for economics (1978), and contributing philosopher of science - was no dilitante. This book, which is written is a very accessible style, reveals the integrity and evolution of his thinking, which can be extracted only with relative difficulty from his large and diverse literary corpus. It is also an inspiring book for any person with an active intellectual life in science or philosophy.

Thomas J. Hickey, www.philsci.com

Renaissance Man of the 20th Century.......2003-07-19

The late Herbert Simon was a veritable renaissance man. His autobiography, "Models of My Life," discusses the single thread that underlined all of his intellectual conquests in artificial intelligence, sociology, cognitive science, psychology and economics. This one thread, animated by philosophical positivism and ripe scientific thirst, was his deep obsession with modeling and researching decision-theoretic behavior.

It's interesting to note that even though decision theory (how intelligent agents percieve and act upon choices amid various modalities) serves as the impetus for Simons work, he uses "Models" instead of "Model" in the book's title. This is no accident. For you see, beautifully fitting of his memoir, this book delves into how Simon's one passion was his "heuristic" in choosing which of many paths he could have taken througout his life. The upshot: Simon's own life emulated the heuristic search (in AI) that he helped invent! Consequently, this lead him all over the globe, from Wisconsin to UChicago to Berkeley to Carnegie Mellon to China.

This book is also about the times of Simon: the positivistic turn in social sciences, the scientific fermet of the 1950's, the cultural tumult of the 60's, the death of behaviorism and the rise of cognitivism -- all along, peppered with intrigue of the politics of academia. Although the writing can get quite dry at times, his book is highly recommended.

Learn the Why and How of a Distinguished Life.......2002-05-16

Herbert Simon's research contributes to human knowledge in many different areas, including economics, artificial intelligence, cognitive psychology, and organizational behavior. In each of the mentioned areas, his contributions are ranked among the most important and influential that even a scientist who focuses solely in one area finds hard to achieve. The testimony is the top awards that the community in each discipline bestowed upon him--the Nobel prize is only one of which.

The secret of this interdisciplinary success is that he is, in his own word, a "monomaniac", studying only one thing--human decision process--for fifty years. The field of his own choosing is not bounded by usual academic disciplines, however, and he did study it from many different aspects, from the levels of individual cognition to organizational decisions, using tools as varied as mathematics, computer simulations, and human subjects.

This book detailed his own account of the various aspects of his life, personal and professional, in a sincere and direct prose. From the childhood that undoubtedly helped set the tone for his later accomplishments, the way he managed and nurtured new academic thoughts that later grown into full-fledged disciplines (artificial intelligence, cognitive science, and, less prominently, bounded rationality), to the philosophy of working and living including brief exposures to familial life, we can learn tremendously from hise xperience, decisions, and actions.

How could he achieve as much as he did? We can glean several lessons from his stories. He collaborated extensively. He learned a great deal from the outstanding individuals he respected. He had a love for truth and rigor in reasoning. An empiricist who firmly believed that any valid theory must be based on empirical facts, he did not hesitate to fight against widely held beliefs conflicting with facts. His work on bounded rationality which helped earn him the Nobel Prize is an outstanding case which his stubborn, and valid, arguments against mainstream theories brought a valuable alternative viewpoint to the world. Strong passion and the ability to break out of the mold and stand tall under storms are important characteristics exemplified by many past giants, including Galileo, Columbus, and Einstein.

Book Description

Not long ago, Karen Duffy was sitting on top of the world and loving it. From calling bingo in a nursing home, she'd taken the express elevator to the penthouse overlooking success street. She worked as a VJ on MTV, as a spokesmodel for Revlon, as a film actress in Dumb and Dumber and other movies, and as a correspondent on Michael Moore's irreverent, Emmy-winning TV Nation. She was selected as one of People magazine's "50 Most Beautiful People in the World" in the same year she won the Ernest Borgnine Look-alike Contest.

But suddenly Duffy's whirlwind life of celebrity parties and socializing with friends from George Clooney to Jim Carrey to Richard Gere came to an abrupt, grinding halt when she was stricken with a serious illness in one of its rarest forms: sarcoidosis of the central nervous system. The disease left her partially paralyzed, in tremendous pain, and at times near death.

Although she had a serious disease, Duffy soon realized that the only way for her to survive was not to take the disease too seriously. Instead of hiding from life, she chose to run toward it. She learned to embrace the chaos of a life-threatening disease with a wit and humor that helped her to find the love of her life at a time when things seemed darkest.

Model Patient is a gripping, inspiring, and hilarious memoir that recounts the singular triumphs and tragedies of coping with a chronic, life-threatening disease.

Model Patient is an unforgettable, illumnating story that captures Duff's indomitable joie de vivre, revealing how she lives and how she has survived.

Customer Reviews:

Karen Duffy is Trash...........2007-08-15

If you saw her MTV reporting, The Revlon and other beauty Tv adds she did, and more recently hosting really awful reality based TV shows, then you can tell she's trash. Only she can take a bad disease and turn it into some sort of name calling trash book which this is. Please do not bother with her or anything she writes.

Disease and a positive outlook.......2007-03-09

Karen Duffy writes about her affliction with a somewhat uncommon disease in a biographical tale that combines a story about her interesting life with a story about her life dealing with the trials and tribulations of sarcoidosis,a chronic inflammatory disease that affects many different parts of the body.Her wonderful sense of humor and upbeat attitude make this book most entertaining as well as inspiring.

I couldn't make myself finish it!.......2005-12-30

Duffy's storytelling is full of name dropping and "my life is so cool" immaturity that I couldn't make myself read more than a couple of chapters, and that was more painful than my sarcoidosis. This book is awful!

Rachel Ray 30 or DUFF?! No contest!.......2005-03-24

After spending way too much time contemplating which RR tome to add to my collection I stumbled upon an episode of Party Planning with Dave Tuterra (sp?) and instantly decided to get Karen's new book instead. LOVE IT!

I am about 35 years old and I grew up thinking Karen Duffy was ABSOLUTELY the hottest and coolest VJ/ model on the planet! I wanted to live her life, have her job, and sleep with her boyfriends! If anyone could convince me to "play for the other team" it would have been her. My girlfriends and I even used her moto- "We're getting married in May- may the day never come!"

I actually cried when I heard about her illness which was regarded as terminal at the time. I read Model Patient- her book about her struggle with CNS Sarcoidosis and was amazed that the icon of party, rock and roll and pop culture could be such a strong and resilient person underneath.

Now, like the rest of us she has traded in the club scene and coctails for marriage and motherhood.
Her new book 'Slob in the Kitchen" is not for the refined foodie that wants to spend hours preparing a jaw dropping meal, but for people that need to make dinner. Preferably one that the kids will eat. Highly recommend!

Not Homer Simpson's kind of Duff........2004-01-01

Everyone wants to be a star, but no one wants to literally crystalize internally from sarcoidosis. That is the life, onscreen and off, of Karen "Duff" Duffy.

For the unbaptised, if Match Game were still around, Karen Duffy is the kind of all-around celeb that would be the next Brett Somers - Wiseacre, Girl Friday, Broad-in-the-making. She also meets the pain of a chronic disease with a glee that most people could not summon.

Book Description

"Once upon a time there were three men who exemplified, without knowing it, my ideal in life. All of them became famous as writers, influential thinkers, and public figures. Their names are Clifton Fadiman, Lionel Trilling, and Jacques Barzun. They met in college, they remained aware of one another as friends or, if less than friends, companions and fellow crusaders on behalf of similar ideals. Although one of them never knew of my existence, the second ignored it, and the third treated me with formal kindness, without them I would have had no concrete model in my youth of what I wanted to become. Theirs was the universe in which I wished to have my being."

With these words, Carolyn Heilbrun begins a personal, pointed, and surprisingly moving account of how a woman, destined to become one of the leading feminist critics of her day as well as one of our most popular mystery novelists, found the models for the life she aspired to in men who neither imagined nor countenanced women as their equals or colleagues. Remembering these three figures as they were when she hung upon their printed words and professorial presences, reappraising them now half a century later, Heilbrun vividly evokes what these remarkable individuals had to offer to an admiring young woman who could not acknowledge--and later would not accept--the impossibility of following in their paths.

In the admired anthologies, magazine articles, and introductions through which Fadiman transmitted the world of high culture to an educated general public, he indicated no devotion to questions of female destiny; yet long before Heilbrun could imagine the life in the academy that was denied to Fadiman but would eventually be hers, his was the career to which she privately aspired. Later, in her days as a graduate student at Columbia, it was Trilling who would have the most powerful intellectual effect upon her, formulating as he did the tensions inherent in the desire to salvage what was of worth from a sad, almost moribund culture, even if he frankly admitted to no interest in teaching women or in considering their destinies beyond the domestic sphere. Only the courtly Barzun, also a mentor at Columbia, seemed capable of respecting female accomplishment and eschewing stereotyped views of women. Yet together, all three men unconsciously made Heilbrun's life as a feminist possible, by representing both what she wished to join and what she needed to struggle against.

When Men Were the Only Models We Had is a loving, admiring, but stringent account of youthful enthusiasms, of the romance of ideas, of the intellectual brilliance of three unwitting mentors, and of the hopelessness of female ambition in the years before the feminist movement of the last three decades of the last century. And it is, in the end, a book that offers splendid proof that the models we once had are no longer the only ones before us.

Customer Reviews:

tragedy is what most marks us if we are thinkers ... .......2006-08-16

Since I took a graduate seminar course in women's memoirs in American literature, I have read several books by Heilbrun. As I was not going to specialize in autobiography/memoirs or in feminist theory, I read her more as a writer than a scholar or theorist, focusing more on how she says things than on what. In this regard, I enjoyed every book I read because her language was something unique. It is clear and concise, without being simple, authoratitive without being pedantic, seemingly aloof yet strangely persuasive. If passion is another name for talent, she is very, very passionate, but that passion is moderated with a unique kind of resignation (or perhaps, wisdom).

This book is not my favorite, and compared to other titles such as Writing Women's Lives, it does indeed gets slow and heavy here and there. There are parts where even those in the same line of work as Heilbrun's would go, "Who cares?" or "Why bother?" Yet, largely, it is accessible and *fun*. Read as an intellectual memoir, it is a story about how Heilbrun was gratefully influenced by three men, how she resisted and embraced their influence, and how she finally grew out of it. There are many interesting anecdotes coming from her encounters with these men (Barzun, Fadiman, and Trilling) and her life as a graduate student in the 50s at one of the most highly regarded universities in the US. Students of today would gasp at the nightmarish inconvinience of having only two copies of their papers, and painfully taking turns in reading other student's papers due to the lack of copies.

Heilbrun devoted a chapter to Diana Trilling, which wasn't her plan when he planned on the book. She was fascinated and gained admiration for her in the process of research for the book, and readers would clearly see why in the chapter on her. In sum, according to Heilbrun, Diana Trilling is a woman whose insights on her life come largely from feminism ("the most successful revolution of our century," Trilling herself called it), yet who was not herself a feminist. She accepted a life of belittlements from others, while having penetrating understanding of those belittlements.

Early in the book, Heilbrun notes that perhaps one of the most palpable influences she got from Lionel Trilling would be the notion that "tragedy is what most marks us if we are thinkers." This is what Trilling shares with Freud, and this is what Heilbrun shares with Trilling, despite her distrust of Freud, and to some extent, of Trilling as well. This comment comes after an anecdote about Trilling's inspiring lecture on Henry James, from which young Heilbrun took the idea that "the essence of literature was in the tensions of the thinking life." This part of the book is strangely moving, and makes me think hard about the interplay among "tension," "thinking life," "tragedy," and "literature." A small and not really an ambitious book, but contains much fun and insights.

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My Life With Model Trains
Howard Zane
Manufacturer: Howard Zane
ProductGroup: Book
Binding: Hardcover

Model Trains | Crafts & Hobbies | Home & Garden | Subjects | Books
ASIN: B000JQKG9A

Product Description

12.5x12.5" oversize, cloth with dust jacket. from the publisher: '"My Life with Model Trains" is a journey inside the hobby told only as author and master modeler Howard Zane can. It is a feast for the imagination and mesmerizing read for anyone who ever wanted to "play with trains" -- serious hobbyists and enthusiasts, collectors of railroadiana, appreciators of the fine art in design and technique -- and all the dreamers and wannabes with yearnings still stirring from the model trains of their youth. 'Howard Zane's 2,850 square foot "Piermont Division", showcasing his artistry in model railroad building and design, is acclaimed as one of the finest and largest private layouts in the country. Exquisite eye level photography pulls you into the world of the Piermont, over 22 scale miles of track, past the historically accurate architecture, scenery, trains, and vignettes of mythical towns in a romantic recreation of another time and place inspired by Northern West Virginia in the ten years from the end of World War II to the mid-Fifties. You can almost hear the rumbling of trains on the tracks. 'There is no other book like it, inviting you in to share the personal experiences of one of the most prolific master model railroaders and scale structure designers in the country. A captivating story-teller, Howard shares humorous tales chronicling his life as a model railroader, hobby shop owner, a purveyor and expert appraiser of brass trains, and his 25 years as producer of "The Great Scale Model Train Show", the largest show of its kind in the country.'

Help, I'm Being Intimidated by the Proverbs Thirty-One Woman: My Battles with a Role Model Who's Larger than Life

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Nonstop laughs for real women
a laugh out loud account of real life

Help, I'm Being Intimidated by the Proverbs Thirty-One Woman: My Battles with a Role Model Who's Larger than Life
Nancy Kennedy
Manufacturer: Multnomah
ProductGroup: Book
Binding: Paperback

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ASIN: 0880707313
Release Date: 1995-01-01

Book Description

In Help! I'm Being Intimidated by the Proverbs 31 Woman, author Nancy Kennedy tackles this sense of intimidation when she decides to be just like Mrs. P. 31.--perfect--with understandably disastrous and side-splitting results. While acknowledging the

Customer Reviews:

Nonstop laughs for real women.......2002-03-01

This book helped me put a modern perspective on being a Christian woman, all the while making me laugh at some of the attempts at striving to be the "Proverbs Woman." Between all the laughter, though, there were epiphanies that remind us that we are still human and will sometimes fall short. But if we keep God number one in our lives, He will reward us. It's nice to know that I'm not the only one who tries hard with good intentions only to have them turn out disasters!

a laugh out loud account of real life.......1999-12-12

From the minute I picked up this book, my mouth hurt from laughing so hard. And what a great outreach tool! My laughter at the pool (while on vacation) brought many people to me to ask what I was reading - I was able to tell them about this wonderful account of motherhood/wifehood/womanhood, and open up a discussion about faith, God, Christianity, and how it all relates to everyday foibles.

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Mannequin : My Life As a Model

Manufacturer: Bantam
ProductGroup: Book
Binding: Mass Market Paperback
ASIN: B000DEMV3W

Make-A-Saurus: My Life with Raptors and Other Dinosaurs

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Make-A-Saurus: My Life with Raptors and Other Dinosaurs
Brian Cooley , and Mary Ann Wilson
Manufacturer: Annick Press
ProductGroup: Book
Binding: Paperback

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ASIN: 1550376446

Book Description

Here's an exciting new approach to the realm of dinosaurs. World-class dinosaur sculptor Brian Cooley takes kids on a journey into the recent past, when dinosaurs were thought to be cold-blooded, lumbering, solitary creatures. As Brian explains, paleontologists went on to discover new fossils that proved dinosaurs were lean, swift and gregarious. This shift in viewpoint was dramatic, but today there is an even more radical development: the overwhelming evidence indicates that some dinosaurs were feathered, the ancestors of avian life as we know it today.

In Make-a-saurus, Brian reveals just how paleontologists were able to establish that some dinosaurs had feathers. Then he shows how he builds his own feathered model. First, he gathers all the information he can about how the dinosaur looked, beginning with the skeleton. The next step for Brian is creating a rough sketch of the creature, before moving on to shaping the model and applying the fine details. Photographs taken during each step of the process enable children to see a life-like dinosaur model grow before their eyes -- one that recently appeared in National Geographic.

In the last section of the book, Brian adapts his professional model-building for children, telling them how to construct their own dinosaur -- feathered or rough-skinned -- with clear, easy-to-follow instructions, using inexpensive, easy to find materials like wire, tape, papier maché and even dryer lint! Brian brings a light, bright touch to the instructions, so children can truly enjoy creating a dinosaur of their own -- one that can be handled and played with, not just shelved.

"If you want a dinosaur to look as if it could walk right off the pedestal and bite you, you would hire Brian Cooley." (Chris Sloan, Art Director, National Geographic)

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Mannequin; my life as a model
Carolyn Kenmore
ProductGroup: Book
Binding: Unknown Binding
ASIN: B00005WD26

About My Father's Business: The Wisdom of Mose Jones - Father, Role Model, Farmer, Church Leader, Community Leader, Entrepreneur, Veteran

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About My Father's Business: The Wisdom of Mose Jones - Father, Role Model, Farmer, Church Leader, Community Leader, Entrepreneur, Veteran
J.D., Frederick, D. Jones B.A.
Manufacturer: Booklocker.com, Inc.
ProductGroup: Book
Binding: Paperback

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ASIN: 1601450923

Book Description

About my Father's Business is the story of an American sharecropper who defied the odds and became a success. Mose Jones is a community and church leader, role model, and entrepreneur but, above all, the father of fourteen successful children.

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