LC/MS: A Practical User's Guide

Book Description

A practical guide to using and maintaining an LC/MS system

The combination of liquid chromatography (LC) and mass spectrometry (MS) has become the laboratory tool of choice for a broad range of industries that require the separation, analysis, and purification of mixtures of organic compounds.

LC/MS: A Practical User's Guide provides LC/MS users with an easy-to-use, hands-on reference that focuses on the practical applications of LC/MS and introduces the equipment and techniques needed to use LC/MS successfully. Following a thorough explanation of the basic components and operation of the LC/MS system, the author presents empirical methods for optimizing the techniques, maintaining the instrumentation, and choosing the appropriate MS or LC/MS analyzer for any given problem.

LC/MS covers everything users need to know about:

The latest equipment, including quadrupole, time-of-flight, and ion trap analyzers
Cutting-edge processes, such as preparing HPLC mobile phases and samples; handling and maintaining a wide variety of silica, zirconium, and polymeric separation columns; interpreting and quantifying mass spectral data; and using MS interfaces
Current and future applications in the pharmaceutical and agrochemical industries, biotechnology, clinical research, environmental studies, and forensics

An accompanying PowerPoint® slide-set on CD-ROM provides vital teaching tools for instructors and new equipment operators. Abundantly illustrated and easily accessible, the text is designed to help students and practitioners acquire optimum proficiency in this powerful and rapidly advancing analytical application.

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Presents technical data in an easily understood format, explains how to keep LC/MS systems up and running, and shows how to interpret and quantitate the mass spectral data using proven spectral databases, without devolving into a university-style course curriculum. Takes a purely practical approach to using and maintaining LC/MS systems Introduces the reader to quadrupole and ion trap analyzers, which make up the bulk of the equipment being sold for laboratory and analytical studies Presents technical data in an illustrated, easily understood format Explains how to keep systems up and running Shows how to interpret and quantitate mass spectral data using proven spectral databases

Customer Reviews:

a very good start point.......2006-04-24

A good introduction. But not for specialist. Some practical tips are useful.

Troubleshooting HPLC Systems: A Bench Manual

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Troubleshooting HPLC Systems: A Bench Manual, by Sadek

Troubleshooting HPLC Systems: A Bench Manual
Paul C. Sadek
Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Spiral-bound

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ASIN: 0471178349

Book Description

A complete, up-to-date guide to the use, maintenance, and troubleshooting of HPLC systems

The last twenty-five years have seen a dramatic rise in the use of High Performance Liquid Chromatography (HPLC) in laboratories worldwide. Troubleshooting HPLC Systems provides analysts as well as laboratory technicians and managers with a readily accessible and immensely useful guide to the new generation of HPLC equipment and techniques. With an emphasis on effective troubleshooting of HPLC systems, this lab companion covers system configuration and functions, problem-solving procedures, maintenance, and HPLC basics. It then walks chromatographers investigating the source of a malfunction through each system component-from solvents and reservoirs to sample preparation to columns and detectors. Special features of Troubleshooting HPLC Systems include:
* A detailed review of HPLC instrumentation and accessories
* The role of operating parameters as indicators of system performance
* Step-by-step troubleshooting protocols for each system component
* How to set up a preventive maintenance program for HPLC systems
* An overview of the categories of HPLC separations
* A compilation of HPLC terms and definitions
* Tables and charts detailing solvents' properties

Customer Reviews:

Troubleshooting HPLC Systems: A Bench Manual, by Sadek.......2001-09-30

I thought that this was an excellent book. It provided lots of the practical kind of details that I was looking for. This book is great for someone who has either limited or no experience in HPLC. It would also work as a refresher, for someone who has been out of the field for some time.

Stability-Indicating HPLC Methods for Drug Analysis

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Stability-Indicating HPLC Methods for Drug Analysis
Quanyun A. Xu , and Lawrence A. Trissel
Manufacturer: APhA Publications
ProductGroup: Book
Binding: Hardcover

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ASIN: 1582120463

Book Description

Stability-Indicating HPLC Methods for Drug Analysis compiles summaries of stability-indicating HPLC analytical methods that have appeared in the published literature. A first stop for pharmaceutical scientists, analytical chemists, and librarians in the quest for information about the stability of drugs. Co-published by the American Pharmaceutical Association and the Pharmaceutical Press, a division of the Royal Pharmaceutical Society of Great Britain.

Pulsed Electrochemical Detection in High-Performance Liquid Chromatography

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Pulsed Electrochemical Detection in High-Performance Liquid Chromatography
William R. LaCourse
Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Hardcover

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ASIN: 0471119148

Book Description

A reliable, comprehensive, relevant view of HPLC and its applications

The development of HPLC-PED represents the successful marriage of two powerful analytical technologies and has resulted in the best technique for sensitive and direct detection of biological compounds with poor optical detection properties. PED has been used extensively for the determination of carbohydrates and other polar aliphatic compounds, and as a result, numerous methods have been developed to enable the analysis of a wide variety of samples. Over the years, many articles, anecdotal information, and misinformation have permeated the scientific community, with the possible consequence of confusion or uncertainty with regard to PED on the part of the analyst. Pulsed Electrochemical Detection in High-Performance Liquid Chromatography presents a reliable, comprehensive, and relevant review of HPLC-PED and its applications.

The book is divided into three major parts: background material necessary for a more thorough understanding of the principles and relevance of PED; an in-depth discussion of PED using voltammetry and other electroanalytical techniques and presenting the advantages, applicability, and optimization of all existing PED waveforms; and practical aspects of HPLC-PED, including a summary of the major applications and a look at future developments in the technique. Appendices include a pulsed voltammetry (PV) program specifically written to optimize pulsed amperometric detection (PAD) waveforms and all the known applications, categorized and listed in tabular form.

For analytical chemists; biochemists; carbohydrate chemists; biotechnologists; undergraduate, graduate, and postdoctoral students; and lab technicians working in a range of areas including the pharmaceutical, medical, and food and beverage industries, this eminently readable guide is the first reliable book-length treatment of how to use PED coupled with HPLC.

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So brilliant that I cried--twice!
Basic HPLC and CE of Biomolecules

Basic HPLC and CE of Biomolecules
Robert L. Cunico , Karen M. Gooding , and Tim Wehr
Manufacturer: Bay Bioanalytical Laboratory, Inc.
ProductGroup: Book
Binding: Paperback

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ASIN: 0966322908

Book Description

This text provides explanations and examples of the primary chromatographic techniques for biomolecules (reversed-phase, size exclusion, ion-exchange, hydrophobic interaction and affinity). It also offers practical suggestions for their implementation and optimization. An extensive bibliography furnishes a wealth of background information.

Customer Reviews:

So brilliant that I cried--twice!.......2003-04-25

This is without a doubt the most brilliant and poignant depiction of HPLC and CE of biomolecules in modern history. My extreme hyperactivity disorder usually means that I'm not able to sit still for such weighty topics--not without large amounts of abused Ritalin; but Cunico's work was so compelling and finely wrought that I found myself spellbound, even when drunk, even when driving in the backseat of a stolen car across the Mexican border at Tecate. I am not going to recommend drinking heavily and stealing cars. But I do recommend BASIC HPLC and CE OF BIOMOLECULES by Robert L. Cunico. By the way, I am extremely drunk right now.

Basic HPLC and CE of Biomolecules.......2000-12-24

This is a book that should be on the desk of anyone who is involved in analytical development of biomolecules and biopharmaceuticals. The content is well organized and written in a format that is easy to grasp and understand. The content covers almost all the different modalities of HPLC analyses and applications and provides real life examples of the techniques. It includes innumerable suggestions on how best to develop a validatable HPLC method and analyze the data appropriately.

Book Description

An in-depth guide to HPLC column technology High-performance liquid chromatography and its derivative techniques have become the dominant analytical separation tools in the pharmaceutical, chemical, and food industries; environmental laboratories; and therapeutic drug monitoring. Although the column is the heart of the HPLC instrument and essential to its success, until now, no book has focused on the theory and practice of column technology. HPLC Columns provides thorough, state-of-the-art coverage of HPLC column technology for the practicing technician and academician alike. Along with a comprehensive discussion of the chemical and physical processes of the HPLC column, it includes fundamental principles, separation mechanisms and available technologies, column selection criteria, and special techniques. Special features include:
* Comprehensive overview of state-of-the-art HPLC column technology
* Explanation of the underlying principles of HPLC columns
* Methods for selecting columns
* Practical advice on using and applying columns, including examples
* Section by M. Zoubair El Fallah on methods development
* Special techniques, including preparative chromatography, continuous chromatography, and the simulated moving bed
* Troubleshooting section
HPLC Columns helps laboratory practitioners make better choices in column selection, methods development, and troubleshooting: it is also an excellent textbook for graduate-level courses and HPLC short courses.

High-Performance Liquid Chromatography and Lipids: A Practical Guide

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High-Performance Liquid Chromatography and Lipids: A Practical Guide
William W. Christie
Manufacturer: Pergamon
ProductGroup: Book
Binding: Hardcover

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Troubleshooting LC Systems: A Comprehensive Approach to Troubleshooting LC Equipment and Separations

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Troubleshooting LC Systems: A Comprehensive Approach to Troubleshooting LC Equipment and Separations
John W. Dolan , and Lloyd R. Snyder
Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0896031519

Book Description

Major advances in instrumentation and technology have made high-performance liquid chromatography (HPLC) a pervasive tool in virtually all areas of chemical and biomedical research today. Despite HPLC's enormous growth, technical problems still bedevil most users at least occasionally.

Based on their immensely successful short courses, Dolan and Snyder's landmark new book --Troubleshooting LC Systems--now makes available to every practicing chromatographer the authors' wealth of expertise from years of hands-on troubleshooting of real-world LC problems--problems that routinely cause crises and unproductive downtime in nearly every lab.

Believing that successful troubleshooting requires an understanding of the basics, Dolan and Snyder open by setting forth all the fundamental principles of LC operation, then move on to a microscopic description of all the elements of LC devices, to lay out their optimal preventive maintenance routines, and ultimately to offer an unprecedentedly thorough treatment of each and every facet of troubleshooting.

Displaying a special tutorial mastery--honed to a fineness during their ongoing teaching and consulting activities, and a well-received feature column in LC Magazine--the book's chapters cover: automation and robotics • approaches to troubleshooting • reactions of samples • basic separation techniques • valves, tubing, syringes • band broadening and tailing • preventive maintenance • column packing and flushing • individual LC modules • troubleshooting principles • reagents and buffering • specific problems in separation • ghost and vacancy peaks • quantitation and calibration • pumps, seals, and pistons • gradient elution problems • column composition • concentration and blockages • sample cleanup • temperature and mixing effects • detectors and recorders • column packing and flushing.

In short, Dolan and Snyder's eminently practical new guide to Troubleshooting LC Systems is an essential laboratory handbook--one that empowers expert and novice chromatographer alike to solve every sort of practical laboratory problem on a day-to-day basis. No one using an LC system should be without it!

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Another Stellar Piers Anthony Series
Key to Chroma a great sequal to read!
A new highlight in my library

Key to Chroma
Piers Anthony
Manufacturer: Mundania Press LLC
ProductGroup: Book
Binding: Paperback

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ASIN: 1594260184

Customer Reviews:

Another Stellar Piers Anthony Series.......2007-02-21

Key to Chroma is the second book in the Chromagic Series. This series was refused publication by many companies until Piers went to Mundania Press. Those previous publishes are fools indeed and i am sure they feel that way by this point. This is another killer series from Piers Anthony. If you love his Xanth series then you will also enjoy this series. Piers weaves an amazing story with some truly original concepts in the fields of magic. (Sorry no spoilers) Fans of his other series will notice some familiar concepts, sex being the most obvious of those. However in this series sex in not just a byplay in the novel but a fully integral part of it. This is another example of Piers amazingly complex mind with an incredible penchant for originality. The "No Fault" concept he introduces will shock and amuse many. By no means a cheap side series the story and plot-line are awesome. That this series was turned down is still a fact i have trouble believing. The sceneries and landscape painted in this novel are so varied and original that it could never be made into a movie. Only the imagination could ever give credit to this books descriptive magnitude. This book Key to Chroma is not just an interlude between the conclusion and the beginning of the story. Piers writes in enough background information that this could be a stand alone book without making readers of the series get a feeling of redundancy. Not the best series ever written and not the best Piers has ever written, but definitely a must read. I enjoyed it immensely.

Key to Chroma a great sequal to read!.......2004-06-18

Key to Chroma, is a fantastic follow-up for its sequel, Key to Havoc. Not only do we learn more about the changelings but also about the "all powerful" Glamours. This novel has more adventure, action and romance than the first one and as a bonus there is all this small short stories inside the main storyline that can stand all by itself. My favorite is in chapter 5, titled "Dancer." It is one of the sweetest story ever that Piers has written. It is really in the tradition of the Arabian Nights stories. Sex is still a made component of the series and this novel doesn't lack on steamy sex scenes but also have sex scenes that really make you realize the different between just having sex and making love, so it is really nice to find a balance between romance and sex in this novel.

Also, this sequel really expand in the nature of the Chroma magic and Glamour magic and the challenges and the conclusions are very satisfying to read.

I highly recommend this novel and I can't wait for the next one, Key to Destiny! It is so nice to read something totally new from Piers that is not Xanth. I love Xanth but I do miss his SF/Fantasy novels like the Incarnations series or the Apprentice Adept series. This novel follow the Piers' tradition of great storytelling. If you want an adult novel full of fun and action, buy Key to Chroma and read it, you will not regret it.

A new highlight in my library.......2004-02-14

I didn't know Piers Anthony was even writing this series of books but when I found the first book in the series and read it, I had to have the second. After having finished the second, I can't wait for the third. The characters develope before your eyes and you need to know what is going to happen next. It is one suprise after another to keep you guessing. If you love to read Piers Anthony books, this series is a must read.

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HPLC of Polymers (Springer Laboratory)
Harald Pasch , and Bernd Trathnigg
Manufacturer: Springer
ProductGroup: Book
Binding: Paperback

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ASIN: 3540655514

Book Description

Polymers are mainly characterized by molar mass, chemical composition, functionality and architecture. The determination of the complex structure of polymers by chromatographic and spectroscopic methods is one of the major concerns of polymer analysis and characterization. This lab manual describes the experimental approach to the chromatographic analysis of polymers. Different chromatographic methods, their theoretical background, equipment, experimental procedures and applications are discussed. The book will enable polymer chemists, physicists and material scientists as well as students of macromolecular and analytical science to optimize chromatographic conditions for a specific separation problem. Special emphasis is given to the description of applications for homo- and copolymers and polymer blends.

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