Molecular Gastronomy: Exploring the Science of Flavor (Arts and Traditions of the Table: Perspectives on Culinary History)

Book Description

Hervé This (pronounced "Teess") is an internationally renowned chemist, a popular French television personality, a bestselling cookbook author, a longtime collaborator with the famed French chef Pierre Gagnaire, and the only person to hold a doctorate in molecular gastronomy, a cutting-edge field he pioneered. Bringing the instruments and experimental techniques of the laboratory into the kitchen, This uses recent research in the chemistry, physics, and biology of food to challenge traditional ideas about cooking and eating. What he discovers will entertain, instruct, and intrigue cooks, gourmets, and scientists alike.

Molecular Gastronomy, This's first work to appear in English, is filled with practical tips, provocative suggestions, and penetrating insights. This begins by reexamining and debunking a variety of time-honored rules and dictums about cooking and presents new and improved ways of preparing a variety of dishes from quiches and quenelles to steak and hard-boiled eggs. He goes on to discuss the physiology of flavor and explores how the brain perceives tastes, how chewing affects food, and how the tongue reacts to various stimuli. Examining the molecular properties of bread, ham, foie gras, and champagne, the book analyzes what happens as they are baked, cured, cooked, and chilled.

Looking to the future, This imagines new cooking methods and proposes novel dishes. A chocolate mousse without eggs? A flourless chocolate cake baked in the microwave? Molecular Gastronomy explains how to make them. This also shows us how to cook perfect French fries, why a soufflé rises and falls, how long to cool champagne, when to season a steak, the right way to cook pasta, how the shape of a wine glass affects the taste of wine, why chocolate turns white, and how salt modifies tastes.

Customer Reviews:

Entertaining but not the best cooking reference.......2007-10-08

I was looking for something to use as a reference for how to prepare different types of food. This definitely is not it. It is an entertaining read but it does not really have the level of detail I was looking for when I got this book. The best I have gotten so far is On Food and Cooking: The Science and Lore of the Kitchen (or something like that) by Harold McGee.

We're that much closer to Jetson style food pills.......2007-06-19

Herve This is a genius and should be respected simply for the fact that he approaches cuisine with something other than blind awe of traditions that regarded as fact but are little more than a step up from superstitions and old wives' tales. Already a bit on the dry academic side and then translated from French to English, it can occassionally be a difficult read, but the unique nature of the subject makes sure it says a fascinating read. The book is broken up into sections each a few pages long asking if and why a preconceived notion regarding food is true (Does the juices of meat really contract to the center when you cook it?, Does it matter if you slowly heat your stock or use hot water from the beginning?), the nature of flavor (how salt affects sweet and bitter flavors), just what goes on with the food before we eat it (What causes cheeses to taste the way they do tracing it all the way back to the diet of the cow), and theoretical ideas to make the culinary field better (Developing new cooking techniques involving technology such as artificial vacuums and electrical fields). While the book uses specific examples, it's easy to take This's basic technique and apply it to anything food related, which you could imagine is his goal, having founded the field sharing its name with the book.

good, but.......2007-05-20

good, but, not very complete, inaccurate and simplistic. if you have read harold mcgee, it is a bit simplistic, un-scientific, and extremely biased. good for the beginner or home cook. short stories (and lack of scientific guidelines) are good for those without the patience for "on food and cooking"...

Disappointing.......2007-05-11

I was hoping to find something along the lines of Harold McGee's "On Food and Cooking". If this is what you are looking for, look elsewhere.

Trick in the kitchen.......2007-03-20

This hardcover is divided in small paragraphs which are dealing with the different topics in kitchen science. The first section is dedicated to the tricks in cooking and is the one I like better. Then the author goes through the new discoveries about how do we perceive taste and flavour.
Good start to get in the argument of molecular gastronomy;)

The Eighth Day of Creation: Makers of the Revolution in Biology

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Wonderful
The Power of Science is not the last answer but the next question
Biomedical research, as it is actually practiced
Great piece of historical writing
A magnificent Eighth Day

The Eighth Day of Creation: Makers of the Revolution in Biology
Horace Freeland Judson
Manufacturer: Cold Spring Harbor Laboratory Press
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ASIN: 0879694785

Amazon.com

In the foreword to this expanded edition of his 1979 masterpiece, Horace Freeland Judson says, "I feared I might seem the official historian of the movement"--molecular biology, that is. If by official he means "authoritative; definitive; the standard against which all others are measured" then his fears are warranted. Detailed without being overly technical, humane without being fulsome, The Eighth Day of Creation tells of molecular biology's search for the secret of life. "The drama has everything--exploration of the unknown; low comedy and urgent seriousness; savage competition, vaulting intelligence, abrupt changes of fortune, sudden understandings; eccentric and brilliant people, men of honor and of less than honor; a heroine, perhaps wronged; and a treasure to be achieved that was unique and transcendent." And in Judson this drama found its Shakespeare.

Customer Reviews:

Wonderful.......2006-04-29

Judson tells the story of the birth of molecular biology and giants who nurtured it. Insightful not just of the challenges of the science itself but also of the lives of the many who shaped it. It instilled a deep sense of appreciation in me for the efforts of the many scientists involved in shaping the field of molecular biology without the aid of the modern tools and techniques we scientists take for granted. Highly recommended for anyone with an appreciation for science especially, undergrduates.

The Power of Science is not the last answer but the next question.......2006-04-11

A gripping drama with the biggest question of all, what is life? That's what "The Eighth Day of Creation" is, a historical drama capturing the characters, the challenges, the thrills and disappointment that makes science the compelling endeavor that it is. It's unfortunate that this book has not been made into what would be a great mini-series.

The brilliance of this book is that it investigates the people behind the science, and how they approach their problems. Some are matters of pure logic to deduce the results such as the deciphering of the genetic code, while others are pure perseverance such as coming up with the physical structure of myoglobin. But what makes the book powerful is that each discovery is a major accomplishment, but that it also uncovers the next question. And Judson follows the line of reasoning to answer the next question. It also explores the human side of science, the fierce faith that an answer exists and that they will find it. You get a flavor of science as it is practiced in James Watson's "The Double Helix" but you get the full meal here.

A warning, while the book goes to great lengths to explain the science, those lacking at least college biology may find the subject matter difficult to comprehend. More valuable for graduate students in any of the sciences, it is a complement to the facts by giving a perspective on how those facts are discovered.

Biomedical research, as it is actually practiced.......2002-06-30

Judson's book, like Tracy Kidder's "The Soul of a New
Machine", stands out for getting it: the passion, the
politics, and the personalities behind scientific
and technological progress, as well as its pitfalls and
cul de sacs. Judson's book, like no other I've read,
captures molecular biology as it is practiced.

I received this book as a gift in 1980 when I was a
college freshman hoping to major in biochemistry.
Today, much as I like to see the biomedical research I
do as a rational, deductive, "hypothesis-driven"
affair, there is unescapably the human element. Think
ego, and all of the other human qualities, respectable
or scorned. Have you seen genome sequencer J. Craig
Venter on the cover of Time (or was it Newsweek?). What
do you think put him there?

Science as a human endeavor was put forth theoretically
in 1962 by historian Thomas Kuhn in his "The Structure
of Scientific Revolutions". Complementing Kuhn, Judson
illustrates it in deliciously readable human terms. For
this reason this book is unmatched and is worth six,
not five, stars.

Max Perutz appears significantly in Judson's story. In
1990, as a beginning graduate student, I had the
priviledge of meeting and conversing with Perutz. He
was just as Judson portrayed him: modest, plodding,
dedicated, pursuing what he might learn from the
structure and properties of hemoglobin. Reading Judson
a decade earlier prepared me for this most important
meeting for me.

Though dated (the story stops about 1975), I heartily
recommend this book to anyone considering a career in
biomedical research. Judson successfully conveys the
human reality of that honorable profession. Some times
it hurts -- crystallographer Rosalind Franklin never
got her due -- but that's the state of the profession.

Great piece of historical writing.......2001-04-23

I loved this book. Before reading it, I had the rather naive view that Crick and Watson discovered the structure of DNA and suddenly "all was light". I hadn't realised the huge effort required over the next twenty years to attain an understanding of the linkages between that structure and the biological processes it codes for. Judson's book tells that story, in detail, and is written at a level that I could follow (as a layperson with a keen interest in science).

Judson talked to the researchers responsible for all the major developments in molecular biology, and quotes extensively from his interviews, so the reader gets a feel for the human side of the great adventure, the sense of community and the rivalries, the frustrations and dead ends as well as the victories.

Be warned that it is not a light or short read. It demands the reader's close attention. Fortunately, though, it is a pageturner that (with only minor exceptions) keeps the reader gripped.

It should also be noted that the first edition of the book was written in the early seventies and, while no doubt Freedland has updated it, the main narrative ends in about 1972. There is a final chapter on developments since then, but it is of necessity quite brief and touches on a limited number of highlights.

A magnificent Eighth Day.......2000-06-13

Wonderful, it is simply the best book on the subject. An account that carefully balances scientific contents and personal issues of the scientists from the early times of molecular biology and conveys the the thrill of professional research.

What Is Life?: with "Mind and Matter" and "Autobiographical Sketches"

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An Absolute Classic from a Great Thinker
Stimulating Reading
A physicist's essay on a topic he cannot know as a scientist, only as a human being
Pons Asinorum? It Wasn't Then !
A Classic

What Is Life?: with "Mind and Matter" and "Autobiographical Sketches"
Erwin Schrodinger
Manufacturer: Cambridge University Press
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ASIN: 0521427088

Book Description

Nobel laureate Erwin Schrödinger’s What is Life? is one of the great science classics of the twentieth century. A distinguished physicist’s exploration of the question which lies at the heart of biology, it was written for the layman, but proved one of the spurs to the birth of molecular biology and the subsequent discovery of the structure of DNA. The philosopher Karl Popper hailed it as a ‘beautiful and important book’ by ‘a great man to whom I owe a personal debt for many exciting discussions’. It appears here together with Mind and Matter, his essay investigating a relationship which has eluded and puzzled philosophers since the earliest times. Schrodinger asks what place consciousness occupies in the evolution of life, and what part the state of development of the human mind plays in moral questions. Brought together with these two classics are Schrödinger’s autobiographical sketches, published and translated here for the first time. They offer a fascinating fragmentary account of his life as a background to his scientific writings, making this volume a valuable additon to the shelves of scientist and layman alike.

Customer Reviews:

An Absolute Classic from a Great Thinker .......2007-08-03

In "What is Life?" monograph, Schrodinger brilliantly enlightens us with the true concept of life science. He proposes what himself calls "a naive physicist's ideas about organisms." Years before the discovery of double helix structure of DNA, Schrodinger beautifully details how the huge volume of information is related to the structure of what he calls "aperiodic crystal" (what we currently call it "protein structure."

The ideas are still fresh and everybody who really wants to start the REAL and TRUE molecular biology must read this classic. It is astonishing to see how this great thinker and physicist had elaborated, very correctly and properly, to use the statistical tools in physics (statistical physics) to explain the fundamentals of life.

It is an absolute classic from a great legend. Please read and enjoy it.

Stimulating Reading.......2006-10-15

Schroedinger, one of the great physicists of the 20th Century, applied the knowledge he gained in his own discipline to analyze human life. Based upon lectures that he gave in the 1940s, this brief book contains Schroedinger's fascinating speculations on the nature of life, several of which have proven prophetic (including the discovery of DNA). The reader comes away with the joy of having shared in the workings of a great mind.

Perhaps the most impressive achievement of the book is that it can be readily understood by persons relatively untrained in science or mathematics.

A physicist's essay on a topic he cannot know as a scientist, only as a human being.......2004-12-19

I'm wondering why scientists are allowed to give their opinion as scientists about topics they know nothing about as scientists. The beginning of the title ("What is Life") sounds like if Schrodinger can claim anything about the difference between mind and matter as a pure consequence of physics. Too bad, as the rest of the title might make you think that there will be some discussion about why and whether there might be a difference between mind and matter. What remains of mind when you stick to the physics? That would be a very nice question to think about, if only this was the topic of the book...but it's not what is done here.

Pons Asinorum? It Wasn't Then !.......2004-08-30

While I was reading the book I thought "this is pretty obvious stuff!" Then I began reminding myself that "If I see further, it's because I stand on the shoulders of giants."
I read the book because J.D.Watson said it was good in his book "DNA The Key To Life." He was right. The first chapter was fascinating.

A Classic.......2004-03-08

What is Life? is an absolute classic. Schrodinger felt that life must be explainable by physics and chemistry, yet seemed to violate the normal behavior of entropy-- and he understood further that this was a remarkable wedge point to explore. He figured out the explanation: life is the result of evolution of genetic information, which selects for complex processes that by ordinary considerations would be very unlikely. He predicted that there must be a molecule capable of carrying the genetic information (incorrectly thinking it would be a protein.) His beautifully-written book was influential and timely. Within 4 years, Von Neumann elucidated the mechanisms involved in self-reproducing automata (illustrating his abstract discussion with a picture looking remarkably like DNA to the eyes of readers today); and within a decade, Watson and Crick grasped the structure of DNA. You should not read Schrodinger's book today as one of your first sources to understand life-- there has been remarkable progress in the 50 years since Watson and Crick-- but you should read it to gain appreciation for how science can be advanced when the time is ready and a wedge point, an apparent conflict between fundamental ideas, is analyzed.

The volume also includes another lecture by Schrodinger, Mind and Matter, which is historically interesting in another way. In Schrodinger's day, the state of understanding had not advanced to the point where it was possible to make as useful conjectures about the structure of mind as of life, and he accordingly felt "[mind] may well be beyond human understanding."

Book Description

Phylogeography is a discipline concerned with various relationships between gene genealogies--phylogenetics--and geography. The word "phylogeography" was coined in 1987, and since then the scientific literature has reflected an exploding interest in the topic. Yet, to date, no book-length treatment of this emerging field has appeared. Phylogeography: The History and Formation of Species fills that gap.

The study of phylogeography grew out of the observation that mitochondrial DNA lineages in natural populations often display distinct geographic orientations. In recent years, the field has expanded to include assessments of nuclear as well as cytoplasmic genomes and the relationships among gene trees, population demography, and organismal history, often formalized as coalescent theory. Phylogeography has connections to molecular evolutionary genetics, natural history, population biology, paleontology, historical geography, and speciation analysis.

Phylogeography captures the conceptual and empirical richness of the field, and also the sense of genuine innovation that phylogeographic perspectives have brought to evolutionary studies.

This book will be essential reading for graduate students and professionals in evolutionary biology and ecology as well as for anyone interested in the emergence of this new and integrative discipline.

Customer Reviews:

Yes, does accomplish what it sets out to do..........2006-03-30

...and for the same reason, I feel deserves 5 stars. This book is on the shelf of all (grad students like myself) who work with phylogeography for a reason: It is complete, and it the first book to grab when starting a project of the sort. Very useful, however lacking in the details one must pick up later to execute analyses.

A good overview.......2001-12-18

This book accomplishes what it sets out to do, synthesize existing material into a simplified text. If you are looking for a good overview, this is a good book. If you are looking for mathmatical detail and methods, this may not be the book for you.

Operators and Promoters: The Story of Molecular Biology and Its Creators

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The other definitive history of molecular biology

Operators and Promoters: The Story of Molecular Biology and Its Creators
Harrison G. Echols
Manufacturer: University of California Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0520213319

Book Description

During the past four decades, molecular biology has dominated the life sciences. Curiously, no participant in this scientific revolution has previously attempted a book-length history of the development of this powerful science. Harrison ("Hatch") Echols provides such an account in Operators and Promoters. A gifted molecular biologist and talented raconteur, Echols relates the intellectual history of the most influential discoveries in molecular biology from his own experiences.
Echols joins his vast knowledge of biology with personal interviews of the principal operators and promoters in the field to convey a captivating side of science--specifically, how the personalities of scientists and their competitive and collaborative relations affect new ideas and discoveries. The author reveals how logic and order often arise only in hindsight from the chaos of discovery; eventual solutions often come from experiments performed for entirely different reasons. Echols also shares his deep-seated feelings for the science itself, communicating his admiration, even awe, for the purity and simplicity with which life systems are organized. This gripping insider's account of the first fifty years of molecular biology ties together the biological questions with the scientific solutions of the people who established the field. It will appeal not only to students and those interested in the development of the discipline, but to anyone intrigued by the human side of science and the process of scientific inquiry and discovery.

Customer Reviews:

The other definitive history of molecular biology.......2004-11-12

Hatch Echols was a well-known biologist. He spent years working on a personal history of his field. After his untimely death, his widow completed the manuscript. This book is the result. It is a history of molecular biology from about 1948 to about 1990. By molecular biology he means the attempt to understand biology using the tools of physics and chemistry. It is a superb book, as makes a fine compiment to the OTHER definitive history of molecular biology, Horace Freeland Judson's "Eighth Day of Creation". Judson's 1979(I think) book was a detailed account of three or four episodes in molecular biology, and stopped at 1970. Echols'book gives a much broader overview, focusing on the questions that arose and the people who answered them. The margins are graced by line drawings of the the major actors, done by the author. The result is a fine account of both the science (briefly) and those who made it. Most of the participants were his friends, and it shows. On the other hand, unlike most books, I am unaware of any animosity or basic unfairness towards any of the participants. Those of you looking for revelations of scandal had best look elsewhere. This is an idyll of discovery. Having studied the subject through textbooks, I enjoyed finding out about the twist and turns, the false starts and blind alleys and leaps in the dark that really lay behind the development of the most exciting science of the last half of the twentieth century. Highly recommended.
This book seems to be languishing in obscurity, and I think Judson's book is out of print. This is deplorable. Another reason to purchase it is because feel Operators and Promoters is a good book to dip into and read a few chapters here and a few there, so you will want to have a copy about the house.
Worth purchasing? Definitely

The Double Helix: A Personal Account of the Discovery of the Structure of DNA (Norton Critical Editions)

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Which edition to get ?
DNA discovery
The drama behind the DNA
Understated Account of a Really Big Event
The Double Helix

The Double Helix: A Personal Account of the Discovery of the Structure of DNA (Norton Critical Editions)
James D. Watson
Manufacturer: W. W. Norton
ProductGroup: Book
Binding: Paperback

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ASIN: 0393950751

Amazon.com

"Science seldom proceeds in the straightforward logical manner imagined by outsiders," writes James Watson in The Double Helix, his account of his codiscovery (along with Francis Crick) of the structure of DNA. Watson and Crick won Nobel Prizes for their work, and their names are memorized by biology students around the world. But as in all of history, the real story behind the deceptively simple outcome was messy, intense, and sometimes truly hilarious. To preserve the "real" story for the world, James Watson attempted to record his first impressions as soon after the events of 1951-1953 as possible, with all their unpleasant realities and "spirit of adventure" intact.

Watson holds nothing back when revealing the petty sniping and backbiting among his colleagues, while acknowledging that he himself was a willing participant in the melodrama. In particular, Watson reveals his mixed feelings about his famous colleague in discovery, Francis Crick, who many thought of as an arrogant man who talked too much, and whose brilliance was appreciated by few. This is the joy of The Double Helix--instead of a chronicle of stainless-steel heroes toiling away in their sparkling labs, Watson's chronicle gives readers an idea of what living science is like, warts and all. The Double Helix is a startling window into the scientific method, full of insight and wit, and packed with the kind of science anecdotes that are told and retold in the halls of universities and laboratories everywhere. It's the stuff of legends. --Therese Littleton

Book Description

The classic personal account of one of the great scientific discoveries of the century.

By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a brilliant young zoologist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest unsolved mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries. With humility unspoiled by false modesty, Watson relates his and Crick's desperate efforts to beat Linus Pauling to the Holy Grail of the life sciences, the identification of the basic building block of life. He is impressed by the achievements of the young man he was, but clear-eyed about his limitations. Never has such a brilliant scientist also been so gifted, and so truthful, in capturing in words the flavor of his work.

Customer Reviews:

Which edition to get ?.......2007-04-18

I ended up getting copies of two different paperback editions.

The Simon & Schuster Touchstone Book, with a little bit of an introduction by Sylvia Nasar, has easy-to-read print and the photographs are pleasantly large. Good for reading in the subway.

But the Norton Critical edition, edited by Gunther S. Stent, is the one to get if you can only afford one. Its typeface leaves much to be desired, and, in my copy, some of the pages are hard to read because the printer seems to have run out of ink in the middle of the job. But the edition has materials that are indispensable for an understanding of this classic work of science. I enjoyed, most of all, Stent's essay "reviewing the reviews," showing both the wisdom (by some) and the foolishness (by others) with which the Double Helix was received by the scientific community.

DNA discovery.......2007-03-18

Excellent book formulating the personalities and egos behind the race for DNA. Interesting and well written. Add a star if you are in the field.

The drama behind the DNA.......2007-03-09

I read this as a requirement for a class but actually found it interesting. It show the human sides to the people behing the discovery of DNA and exposes the drama and gossip going on. It also shows just how difficult it was and is to be a woman scientist (Rosalind's story).
It is a short book, an easy read, I recommend it.

Understated Account of a Really Big Event.......2002-11-08

Clarification is in order. First of all, this is not a substantive science book. For all the significance of the discovery it chronicles, The Double Helix never bothers to explain how, for example, x-ray crystallography actually works, or what the difference between a keto- and an -enol is, or even why Watson's and Crick's discovery brought on a new era in the life sciences. Aspiring students of genetics and molecular biology are urged to inquire elsewhere for answers to these questions.

Second, to label The Double Helix a book on scientific method is almost equally misleading - the reason being that there is no room in the rarefied formalism extolled by the likes of Karl Popper for Watson's subjectivity and sarcasm, not to mention the latter's frequent excursions on nubile au pairs and the deplorable student housing market at Cambridge.

Third (not that it matters for an appreciation of the book, but it's a common misunderstanding), Watson and Crick did not discover DNA itself, or even the function of DNA. Rather, they were awarded the Nobel Prize for solving the molecular structure of DNA.

With those clarifications in mind, The Double Helix is a profitable read. Watson shows us non-scientists that the practice of science is "just" another human endeavor, and not some remote, sterilized activity conducted by emotional eunuchs in white coats. Watson's first-person narrative is downright conversational, as if he's talking shop over a pint of stout in an English pub. He is unabashedly honest about both his ambitions and his naivete (he was only 23 at the time the events in the book took place). And his sometimes scathing portrayals of his colleagues - in all their brilliance and banality - give the impression that working in a world-class research facility is a lot like working anywhere else.

Francis Crick comes across as that certain guy we all knew in college (wherever and whenever that was) - impish and boisterous, egocentric but big-hearted, who might be dapper if he didn't sleep in his clothes, whose eccentricity is the bane of faculty advisors, whose attention is everywhere but on task, whose breath sometimes smells like beer after lunch, and whose serendipitous genius comes through at all the right times. The supporting cast is equally colorful: Maurice Wilkins, the quintessential English academic stuffed corpse; Rosalind Franklin, a Freudian caricature of icy feminine competence in a man's world; the godlike Linus Pauling playing with his tinker toy molecular models in California.

And it wasn't just his colleagues who made Watson's work interesting. There were the aforementioned au pairs, the pubs and the parties and the formal receptions, there was the professional competitiveness between the English and the Americans - with Watson (a Yank in Cambridge) more of an American insurance policy against the Brits getting all the credit for solving DNA if Pauling wasn't fast enough. And there was the Cold War, which had an impact on research priorities and, sometimes, hampered communication in the scientific community.

But most importantly - although Watson never deigns to make this point explicit - The Double Helix is a fascinating chronicle of the scientific method in action, notwithstanding the politics, the distractions, and the idiosyncrasies of the protagonists. The task itself was daunting. Watson and Crick already knew what DNA was composed of, and they knew with some certainty the proportions in which the bases were represented, but there could only be one correct way to put all the pieces together and the haystack was a big one. The researchers were quick to offer and to accept criticism, and false leads were abandoned without regard to ego or sunk time. Even though each wanted to get there first, London shared their findings with Cambridge, Cambridge shared their insights with London, and England and California held nothing from each other for long - admirable examples of the "sociable competition" of science that expedites discovery.

In the end, Watson's and Crick's success relied heavily on Wilkins's and Franklin's crystallography, with important contributions from whomever happened to stop by the lab during the two year period, and insights from conferences and the textbooks and articles Watson happened to read at the time. Creativity, serendipity, and openness to the ideas of others eventually yielded hypotheses, which were tested using Pauling's modeling methods. It could not have been done alone, as Watson makes clear, and the structure of DNA would have been discovered sooner or later. While ultimately it doesn't matter who gets the credit for the discovery, the world seems a better place for James Watson's being involved, if only because The Double Helix is such an entertaining read.

The Double Helix.......2002-10-29

The Double Helix: A Personal Account of the Discovery of the Structure of DNA written by James D. Watson is a rather engaging with a easily readable down to earth style book on the discovery of the structure of DNA. James D. Watson and Francis Crick worked on the structure of DNA, as did other of the time L. Pauling and R. Franklin were hot on the heals of Watson and Crick.

This is the story of how they made history, a story by a scientist about scientists, this is a superbly human tale of how a very unusual 23 year old American saw his chance for scientific immortality and set out to seize it.

If you like reading about about discovery and how it was done, then you'll like this book. Written in a folksy mannor, this is a book that is thrilling as you get to experience the discovery firsthand. Here you'll read about observation, the suspense of making this discovery before others and the mounting tension associated with science. You'll feel Watson's brilliance come through the narrative, his frank tone mixed with humor all making this a fast read, but never boring.

You'll be transported back to college, Cambridge, off to London and Paris, experience things like wine, movies, and girls, but you'll feel the undertone of scientific politics at its finest. This is a very entertaining book about the beautiful experience of making a great scientific discovery.

What Mad Pursuit: A Personal View of Scientific Discovery (Sloan Foundation Science)
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An Account of the Discovery of DNA's Structure and MORE!!!!

People behind the discovery

Insights from a great scientist

An amazing travel in science

Very good book.

What Mad Pursuit: A Personal View of Scientific Discovery (Sloan Foundation Science)
Francis Crick
Manufacturer: Basic Books
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Binding: Paperback

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Customer Reviews:

An Account of the Discovery of DNA's Structure and MORE!!!!.......2005-08-09

+++++

THIS book, by Dr. Francis Crick (June 1916 to July 2004), is partly an autobiography and partly a science book. As for the science part, Crick elaborates:

"I have written [this book] both for my fellow scientists and for the general public [and] believe a [non-scientist] can easily understand most of what I discuss...My advice to the reader, should he or she become stuck in...a [difficult, scientific] passage, is either to persevere or to skip to the next chapter. Most of the book is fairly easy. Don't give up hope just because a few paragraphs seem a little hard to follow."

What, then, is the purpose of this book? Crick tells the reader:

"The main purpose of this book is to set out some of my experiences before and during the classical period of molecular biology, which stretched from the discovery of the DNA double helix in 1953 till about 1966 when the genetic code...was finally elucidated."

(Molecular biology is a branch of biology that studies the chemical and physical principles associated with the composition, properties, and activities of molecules in living cells. The genetic code is the dictionary relating the nucleic acid {such as DNA and RNA} language to the protein language.)

Crick achieves his purpose admirably! He gives us an overview of his main, personal experiences and reveals his thoughts at each period in his life. I especially enjoyed his chapter entitled "The Gossip Test" and his memories about the "RNA Tie Club."

I found the science part especially well done. He explains the science that led up to the discovery of DNA's structure but goes beyond this, explaining such things as the different types of RNA, protein structure, the genetic code, and theory in molecular biology. Everything is well explained and there are many helpful diagrams.

Be aware that Crick decided not to give character sketches of his friends and colleagues especially James Watson (born: 1928), Maurice Wilkins (1916 to 2004), Rosalind Franklin (1920 to 1958) and Linus Pauling (1901 to 1994). In other words, he chose not to include "juicy" gossip in his book. I found this refreshing since I found that in reading other books similar to this one that such character sketches can be distracting to the main essence of the book.

This book does not conclude in the year 1966 since Crick includes a final, long epilogue chapter entitled "My Later Years." This chapter is especially interesting as we are told how he moved on to the field of embryology or developmental biology to become involved generally in human brain science and more specifically in human consciousness. I found his theory of "panspermia" (that "is the idea that microorganisms drifted to the Earth through space and seeded all life on Earth") most interesting.

This book has two excellent appendices that resemble a small course in basic genetics. I found these to be well written.

Included near the middle of the book are over twenty black and white photographs. My favorite is Crick with Wilkins and Watson (as well as famous others like John Steinbeck) at the 1962 Nobel Prize Ceremony.

Finally, my only problem occurs on the inside back flap of the book's dust cover. It says the Crick "shared a Nobel Prize with...Watson and...Wilkins in 1962 for the discovery of the double helix of DNA." Not true! According to the official Nobel Prize internet site, they shared the prize "for their discoveries concerning the molecular structures of nucleic acid and its significance for information transfer in living material."

In conclusion, if you want to know about the life and brilliant intellect of a "genius of modern science," then you have to read this book!!

(first published 1988; acknowledgements; introduction; 14 chapters; photo inserts; main narrative 165 pages; 2 appendices; index)

+++++

People behind the discovery.......2003-01-10

I've always been interested in the stories and scientists behind grand scientific discoveries. Everything seems so glamorous and magical on the news and in the textbooks. I know from experience that no science is as easy as it seems. Here, I read about how people in the different labs competed and worked together, got along and didn't get along, and discovered the structure of DNA as a side project. I was so amused by the anecdote about the RNA tie club that I actually laughed out loud. Each member was to receive a tiepin of one of the amino acids (so of course there could only be 20 members). Crick says he was to be tyr, but he never received his pin. There are even pictures of some of the members with there ties on. I am even more amused now that I'm in graduate school where we really do have an RNA club, but unfortunately no amino acid tiepins. The end of the book tries to get into the science and implications of the DNA structure discovery, but it is too quickly done and in the wrong context to really try to give textbook like information.

Insights from a great scientist.......2002-08-18

At first, I was reluctant about reading this book. What on earth could Francis Crick add to the story of the discovery of the double helix, that had not yet been told by his colleague, James Watson, in his famous book "The Double Helix"? A lot, as it turns out. In fact, the two books rarely overlap. Whereas Watson's book mainly relates his experiences as they worked their way towards discovery, Crick does what he does best: making comments. Also, Crick's book doesn't stop at the discovery of the double helix structure of DNA, as Watson's book does, but continues with the cracking of the genetic code.

Crick's book was written twenty years after Watson's book, and it shows. Watson's book contains a fresh story, the raw material out of which history is shaped. Crick's tale is a digested one: written after all the confusion of the moment had cleared up.

An amazing travel in science.......2000-07-26

I am a graduate student in neuroscience and a book by crick was not without any expectations for me. I feel that the book is totally up to my expectations to feel the diversity of a scientific journey from physics to behavior neuroscience through a mile stone achievement in molecular biology.. In the starting Crick gets little stuck in discussion of existance of God which confuses a bit , but later on it is worth of reading in one go. A bonus point of this book is to know other great scientists of that time and their way of thinking , and an excellent capability of crick to pass the meassages of those souls to the reader in a very readable way.

Very good book........1998-03-06

This book is a very good background to Francis Crick's life. He led a very interesting life and he does a hell of a job describing it. Sometimes this book gets to wordy, but it is still a well written, thorough book.

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Hmmmf!
Blatant Propaganda. Read with Caution
Tells the big picture.
Great Natural History Read For Everyone
The ultimate book of life's secret

DNA: The Secret of Life
James D. Watson , and Andrew Berry
Manufacturer: Knopf
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Binding: Hardcover

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ASIN: 0375415467
Release Date: 2003-04-01

Amazon.com

What makes DNA different from hordes of competitors purporting to help readers understand genetics is that it is written by none other than James Watson, of Watson and Crick fame. He and his co-author Andrew Berry have produced a clear and easygoing history of genetics, from Mendel through genome sequencing. Watson offers readers a sense of immediacy, a behind-the scenes familiarity with some of the most exciting developments in modern science. He gleefully reports on the research juggernaut that led to current obsessions with genetic engineering and cloning. Aided by profuse illustrations and photos, Watson offers an enthusiastic account of how scientists figured out how DNA codes for the creation of proteins--the so-called "central dogma" of genetics. But as patents and corporations enter the picture, Watson reveals his concern about the incursions of business into the hallowed halls of science.

After 1975, DNA was no longer solely the concern of academics trying to understand the molecular underpinnings of life. The molecule moved beyond the cloisters of white-coated scientists into a very different world populated largely by men in silk ties and sharp suits.

In later chapters, Watson aims barbs at those who are concerned by genetic tinkering, calling them "alarmists" who don't understand how the experiments work. It is in these arguments that Watson may lose favor with those whose notions of science were born after Silent Spring. Nevertheless, DNA encompasses both sides of the political issues involved in genetics, and Watson is an enthusiastic proponent of debate on the subject. The book accompanies a 5-part PBS series. --Therese Littleton

Book Description

Fifty years ago, James D. Watson, then just twentyfour, helped launch the greatest ongoing scientific quest of our time. Now, with unique authority and sweeping vision, he gives us the first full account of the genetic revolution—from Mendel’s garden to the double helix to the sequencing of the human genome and beyond.
Watson’s lively, panoramic narrative begins with the fanciful speculations of the ancients as to why “like begets like” before skipping ahead to 1866, when an Austrian monk named Gregor Mendel first deduced the basic laws of inheritance. But genetics as we recognize it today—with its capacity, both thrilling and sobering, to manipulate the very essence of living things—came into being only with the rise of molecular investigations culminating in the breakthrough discovery of the structure of DNA, for which Watson shared a Nobel prize in 1962. In the DNA molecule’s graceful curves was the key to a whole new science.

Having shown that the secret of life is chemical, modern genetics has set mankind off on a journey unimaginable just a few decades ago. Watson provides the general reader with clear explanations of molecular processes and emerging technologies. He shows us how DNA continues to alter our understanding of human origins, and of our identities as groups and as individuals. And with the insight of one who has remained close to every advance in research since the double helix, he reveals how genetics has unleashed a wealth of possibilities to alter the human condition—from genetically modified foods to genetically modified babies—and transformed itself from a domain of pure research into one of big business as well. It is a sometimes topsy-turvy world full of great minds and great egos, driven by ambitions to improve the human condition as well as to improve investment portfolios, a world vividly captured in these pages.

Facing a future of choices and social and ethical implications of which we dare not remain uninformed, we could have no better guide than James Watson, who leads us with the same bravura storytelling that made The Double Helix one of the most successful books on science ever published. Infused with a scientist’s awe at nature’s marvels and a humanist’s profound sympathies, DNA is destined to become the classic telling of the defining scientific saga of our age.

Customer Reviews:

Hmmmf!.......2006-06-21

Well, I read it. It's interesting material and Watson is a good writer. Now back to whatever it was that I was doing.

Blatant Propaganda. Read with Caution.......2006-04-08

To be fair, I enjoyed how the book opened up the world of science to many non-scientists. Written in a understandable and comprehensible way, the book brought to life the life story and persuits of many scientists driving to understand the essence of life: DNA.

However, disaster struck when I got into the section about GM foods. It was clear that Watson was a great advocate of the new technology and he is entitled to that view. However, he utterly and horrible abuses the name of science and in his "scientific analysis" of Genetically Modified foods. First the refutes all protestors saying they have backwater knowledge of the area and that they are heavily influenced by politics. He goes on applies the stereotype that ALL protestors are from the non-scientific community and that they are professional trouble-rousers. This is ofcourse not true.

Summary of Watson's "Scientific" analysis of GM foods:
He first states that the alternative to GM is persticides. By using Genetically modified crops, farms can stop using the extensive array of pesticides. Watson states that all pesticides are bad and horrible for the environment, EVEN the natural pesticides. This is probably true has me makes quite a few examples how what has gone wrong.

However, his second point is that by using genetic technology, scientists can make a plant product a natural pesticide in every cell. This pesticide found naturally in chrysanthemum can paralyze insects that eat it and they die a horrible death. He seems to say that such a natural pesticide is good because it's fund naturally in chrysanthemum (although he previous said that natural pesicides are just as bad). He offers no counter argument for such technology and goes on to call the European food agencies "lazy" for not embracing such a gene. Readers should think for a moment and consider that although the natural pesticide incorporated into all the cells of corn etc is not dangerous, there are many other examples where other pesticides are incorporated into our food. In such a case, no matter how much you was a plant, you can never wash that pesticide away! Science needs to be applied with extreme caution. 10 years of research might not reveal what dangers some chemicals do to us in the long run. For example, when X-ray was first invented, no-one knew of such dangerous so people took x-ray pictures of their full body for fun! Not surprisingly after 30 years these some these people developed horrible cancers as a direct cause of the x-rays being taken. The implementation of a new science must be made with extreme caution and the public has every right to be suspicious of it.

Another argument made by Watson is that we have been manipulating genes for centuries in the cross cultivation of plants (therefore GM is safe and anyone saying it is playing good is a hypocrite). However, I must remind you that GM is completely different from genetic engineering where scientists have complete control over what they want to produce. In some cases scientists can have finer control over cross cultivation, but I must remind you that when our ancestors selectively breeded different species of goat wheat to make the wheat we use today, it took many generations of patient work. Now with a new technology, we can suddenly create a new species out of thin air and plant them with our nice machines. Therefore if we created something that wasn't good and didn't know about it, the results would be devastating cause we would be dealing with a mass of new species all around the globe instead of just our backyard.

Watson also claims that GM foods will help solve the world hunger problem. This is not the main and state aim of GM foods, it is merely a side agenda of big companies like Monsanto who is more concerned about getting a constant supply of income from farmers. I must remind you that GM foods is propelled by capitalism. Capitalism is good until it something messes up such as in the great depression. However, when genetic engineering is concerned, far worse catastrophes can occur if technology is too rapidly implemented. What if the "terminator gene" made all the plants on earth unable to reproduce in 60 years? Such inter-species mixing is rare but it does happen. The world hunger problem cannot be solved at the cost of world annihilation. The technology will eventually mature, but maybe in a few hundred years not a few years.

There are many more examples where Watson plainly ignores the counter argument and just makes a biased counter attack for GM foods. I must remind readers to read this book with extreme caution. GM foods are not as safe as the book makes it sound and you are not an uneducated myth believer you object to GM foods.

Tells the big picture........2006-03-21

This book was a lot of fun to read and I really felt like I learned a lot after I finished. The book talks about genetically modified food and how there was such an outcry by the public when it first came in to the market. People didn't want to eat "Frankestien food". He explains why many things people think are bad about recombinant DNA (putting the DNA of one organism into another) are just misconceptions and that there is more potential for good than bad when it comes to recombinant DNA.
The book did get a little boring for me when it came to the chapter on the human genome project though, but that was the only chapter that wasn't interesting to me.
Even people with a strong science schooling will learn things they did not know from this book. I am a third year biology major and learned a lot. There may be some parts that are difficult to understand if you haven't taken a few science classes, but the book is still worth reading.
If you are a religious person you might get upset by this book because Watson treats evolution as truth and bases quite a bit of reasoning on it. He doesn't try to hide the fact that he is an atheist, but does criticize the religious a little with his tone. (I personally am not religious.)

Great Natural History Read For Everyone.......2005-09-11

I really enjoyed the simple and straight forward story of how the Nobel Prize winners Watson (the author) and Crick (who the book is dedicated to) discovered the genetic code. It is a very readable story of how two scientists from different disciplines came together to reveal one of the great mysteries of life: how genetic traits are inhereted; and how this DNA makes all life on earth possible.

James Watson is a humble scientist and wonderful writer. Science needs more like him and less of the other kind that unfortunately seem to dominate the field.

The ultimate book of life's secret.......2005-08-09

This is a fascinating scientific tale of life's history told by one of science's champions - Dr. Watson. We are fortunate that he is also a gifted writer and story teller. This book is a scientific page turner and by the end of the first few chapters the reader realizes what all the excitement is about. It is an easy read and a good review for people with science background, for others the details might prove challenging but the big picture is certainly within grasp. With the sequencing of the human genome, many aspects of our lives has and will change, this book can help usher us into the new age by teaching us the basics so we can be "DNA literate". I am a clinical physician but this book has awakened the scientist in me. I highly recommend it.

Papillomavirus Research: From Natural History to Vaccines And Beyond

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Papillomavirus Research: From Natural History to Vaccines And Beyond

Manufacturer: Caister Academic Press
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ASIN: 1904455042

Of Molecules and Men (Great Minds Series)

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Of Molecules and Men (Great Minds Series)
Francis Crick
Manufacturer: Prometheus Books
ProductGroup: Book
Binding: Paperback

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ASIN: 1591021855

Book Description

There is probably no one who has a deeper understanding of life's biochemical basis than Francis Crick (b. 1916). In 1962 he jointly won the Nobel Prize (with James D. Watson and Maurice H.F. Wilkins) in physiology/medicine for breakthrough studies on the molecular structure of deoxyribonucleic acid (DNA). In 1966 he published this collection of popular lectures in which he explained the importance of this discovery in layman's terms, emphasizing its wide-reaching implications.

Crick begins with a critique of vitalism, the notion that an intangible life force beyond the grasp of biology distinguishes living organisms from inanimate things. In his second lecture he explores the borderline between the organic and inorganic, presenting an elegantly clear description of DNA's basic structure and function in relation to RNA and myriad enzymes.

In his third lecture Crick anticipates events and trends that have in fact come to pass in the past four decades, including the increasing use of computer technology and robotics in mind-brain research, explorations into right-side versus left-side uses of the brain, and controversies surrounding the existence of the soul.

OF MOLECULES AND MEN is fascinating not only for its historical significance but for its continued relevance to ongoing discussions of many crucially important issues in life science.

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