The Cell Cycle: Principles of Control (Primers in Biology)

Book Description

Cell division is a central biological process: it yields the cells required for development and growth, and supplies the replacement cells to repair and maintain old or damaged tissue. But how does this cell division occur? How is it regulated? And what are the consequences when regulation fails? "The Cell Cycle: Principles of Control" provides an engaging insight into the process of cell division, bringing to the student a much-needed synthesis of a subject entering a period of unprecedented growth as an understanding of the molecular mechanisms underlying cell division are revealed. The book gives the student a complete overview of the process of cell division - from chromosome division, through mitosis, cytokinesis, and meiosis - before exploring how cell proliferation is controlled, and how the cell cycle responds to DNA damage. Finally, the book examines the intrinsic relationship between the cell cycle and cancer, and how a detailed understanding of the cell cycle may lead to new specific therapies to treat the disease. "The Cell Cycle" combines articulate prose with striking full colour illustrations, while the unique Primers in Biology modular structure integrates text, illustrations, definitions, and literature references for each topic into one double-page spread, bringing to the student's fingertips all the tools that they need to master that topic. An understanding of the cell cycle is a central tool in gaining insights into many biological systems and processes. "The Cell Cycle: Principles of Control" is the ideal resource for any student wishing to develop a sound grasp of this vitally important subject. The Online Resource Centre features: for lecturers - figures from the book available to download, to facilitate lecture preparation.

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A good source of pretty pictures for your lecture presentation....
CAUTION: not a good intro to development
An Excellent Textbook
Greatest revolution of text in development

Principles of Development
Lewis Wolpert , Rosa Beddington , Thomas Jessell , Peter Lawrence , Elliot Meyerowitz , and Jim Smith
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0199249393

Book Description

Led by Lewis Wolpert, an influential developmental biologist, this distinguished team of authors presents a new and revised edition of the best-selling and popular textbook Principles of Development. Central to their approach is an emphasis on principles and key concepts as well as the idea
that understanding how genes control cell behavior is the key to comprehending development. The authors assume that students are familiar with the basics of cell biology and genetics but also provide thorough explanations of all key concepts in the text, such as the control of gene activity. The
book focuses on those systems-such as vertebrates and Drosophila-that best illuminate the common principles of development, and also discusses other systems like the nematode and sea urchin. A unique feature of the book is its coverage of plant development, which is usually neglected in other
textbooks but has significant relevance to the field of developmental biology. Full of spectacular illustrations and diagrams, Principles of Development, Second Edition, provides the excellent content and quality design of its predecessor, and also incorporates valuable new material.

Customer Reviews:

A good source of pretty pictures for your lecture presentation...........2005-12-22

I used Wolpert's text for an undergrad developmental course. Given that the test assumes previous coursework in genetics/biochemistry, the content of the book could've been more in depth, especially in the chapters on vertebrates. Sometimes extra detail makes the big picture easier to understand; this book leaves a little too much to mystery and results in a confused reader. The glossary and index leave much to be desired. On a more positive note, the illustrations and photographs are as good as you'll find in any textbook. However, I suggest Gilbert's text.

CAUTION: not a good intro to development.......2003-09-23

I am currently using this text for my 300 level developmental biology class. You know the saying, "a picture is worth a thousand words", well, this book is a thousand words without the pictures. It is very cumbersome to read. You know there is a problem when a book makes more sense when read in reverse. I am being very serious. FOr example, the author will be overly vague in introducing a topic, but still use specific terms without any prior introdution. Vital details necessary to understanding the text are given when needed. Throughout, terms are used before definitions are given, which makes the reader go nuts trying to figure out the meanings of more than half of the sentences.
Seriously, i do not understand the "excellent" reviews that others have given it.
I think it may be true that this book is VERY Comprehensive, but as far as clarity, theres none for students trying to understand the basics and a little more. If you are a professor, and know the material, then this book is probably a pleasure to read.
If you are like me, and just want to have a thorough understanding of the basics of developement, it would be in your best interest to look elsewhere.

An Excellent Textbook.......2000-01-25

Wolpert's developmental biology textbook is evidently an excellent text in its field. The authors are all well recognized in thier research areas. The organization of the text is also very well written. The summary of the concept presented at the end of each chapter is helpful. The figures presented througout the text are clear and the language used to explain them is simple but very understandable. Compared with the well-known Gilbert's text, this text may be less in dept but you can get the concept from this book for only half of the time reading Gilbert's. It is a nice book to have both for the new beginner in the field and for just a quick reference.

Greatest revolution of text in development.......1999-02-01

@I read this book for 2 months. Chapters of regeneration is more impressive than any other chapters.Moreover, I impressed that this bppk is best for beginners and students. Composition is also excellent.

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Principles of Regenerative Medicine

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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Principles of Tissue Engineering, Third Edition

ASIN: 0123694108

Book Description

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.

* Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology
* The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine
* New discoveries from leading researchers on restoration of diseased tissues and organs

The Handicap Principle: A Missing Piece of Darwin's Puzzle

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The full explanatory power of this book is unlikely to be accepted any time soon
Truly Fabulous!
Interesting research
Best book on evolution in many years
I loved it, insightful, entertaining, astounding.

The Handicap Principle: A Missing Piece of Darwin's Puzzle
Amotz Zahavi , Avishag Zahavi , Na'ama Ely , and Melvin Patrick Ely
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0195129148

Book Description

Ever since Darwin, animal behavior has intrigued and perplexed human observers. The elaborate mating rituals, lavish decorative displays, complex songs, calls, dances and many other forms of animal signaling raise fascinating questions. To what degree can animals communicate within their own species and even between species? What evolutionary purpose do such communications serve? Perhaps most importantly, what can animal signaling tell us about our own non-verbal forms of communication? In The Handicap Principle, Amotz and Ashivag Zahavi offer a unifying theory that brilliantly explains many previously baffling aspects of animal signaling and holds up a mirror in which ordinary human behaviors take on surprising new significance. The wide-ranging implications of the Zahavis' new theory make it arguably the most important advance in animal behavior in decades. Based on 20 years of painstaking observation, the Handicap Principle illuminates an astonishing variety of signaling behaviors in animals ranging from ants and ameba to peacocks and gazelles. Essentially, the theory asserts that for animal signals to be effective they must be reliable, and to be reliable they must impose a cost, or handicap, on the signaler. When a gazelle sights a wolf, for instance, and jumps high into the air several times before fleeing, it is signaling, in a reliable way, that it is in tip-top condition, easily able to outrun the wolf. (A human parallel occurs in children's games of tag, where faster children will often taunt their pursuer before running). By momentarily handicapping itself--expending precious time and energy in this display--the gazelle underscores the truthfulness of its signal. Such signaling, the authors suggest, serves the interests of both predator and prey, sparing each the exhaustion of a pointless chase. Similarly, the enormous cost a peacock incurs by carrying its elaborate and weighty tail-feathers, which interfere with food gathering, reliably communicates its value as a mate able to provide for its offspring. Perhaps the book's most important application of the Handicap Principle is to the evolutionary enigma of animal altruism. The authors convincingly demonstrate that when an animal acts altruistically, it handicaps itself--assumes a risk or endures a sacrifice--not primarily to benefit its kin or social group but to increase its own prestige within the group and thus signal its status as a partner or rival. Finally, the Zahavis' show how many forms of non-verbal communication among humans can also be explained by the Handicap Principle. Indeed, the authors suggest that non-verbal signals--tones of voice, facial expressions, body postures--are quite often more reliable indicators of our intentions than is language. Elegantly written, exhaustively researched, and consistently enlivened by equal measures of insight and example, The Handicap Principle illuminates virtually every kind of animal communication. It not only allows us to hear what animals are saying to each other--and to understand why they are saying it--but also to see the enormously important role non-verbal behavior plays in human communication.

Customer Reviews:

The full explanatory power of this book is unlikely to be accepted any time soon.......2007-02-11

In The Handicap Principle, the Zahavis have created a compelling case for a seemingly paradoxical revelation: Strength may only be demonstrated by showing vulnerability.

The simplest distillation of its central tenets is that interspecies or intraspecies communication must be costly in order to be meaningful. While it would be useful for any animal to be able to view another's cardiovascular health, the body provides few outright signals of its internal function ... or does it? Amazingly, many seemingly useless appendages like peacock's tails do precisely that. If a peacock can grow a perfectly symmetrical, useless tail, chances are it's in good physical health otherwise.

When we pause to try to determine which traits are considered beautiful, the likely candidates are those with no obvious survival value (long lustrous hair, unblemished skin, clear eyes, perfect teeth, symmetry, and artfully placed fat deposits). All of these traits are also the ones most vulnerable to parasites, and the first to fade in the event of poor health or old age. These are the last places an animal will put its nutritional resources if it was worried only about its daily survival. It is their very wastefulness that shows their value. While no one literally wears their hearts on their sleeves, our dermis is a fairly good proxy of our overall health. This is precisely because of its exceptional vulnerability.

Indeed, any time a scientist wants to test material properties, he or she usually has to break the sample that is being tested. It is only by showing vulnerability that true (breaking) strength can be gauged.

Thorstein Veblen's The Theory of the Leisure Class, published in 1899, and Nancy Etcoff's Survival of the Prettiest both form interesting companion pieces to this work. The Zahavis demonstrate that Veblen's concept of conspicuous consumption applies to the animal kingdom as well.

Just like The Origin of Species or The Selfish Gene, the Handicap principle is a theory that has yet to be proven. From a scientific perspective, however, a theory is far more than a guess. Theories can be judged primarily for their explanatory power, and all of these works provide considerable ammunition. While The Handicap Principle is by no means proven, it provides an amazing lens through which to view the world. You'll never look at animals (or yourself) the same way again.

Truly Fabulous!.......2003-07-15

I thought that the Zehavis' research and book was outstanding.
I feel this book and their theory is a must for any comprehensive review of the literature on altruism.

Interesting research.......2001-12-15

One problem with this book is that it refutes other forms of cooperative altruism such as reciprocal altruism instead of combining them with the theory and expanding upon them. The Handicap Principle is one of a few theories on explaining cooperative behavior in different species and the authors here give it a good starting point to their theory. It seems that several theories stemming from evolutionary research need to use the cooperation they often rave about and come together to overcome their flaws.

Best book on evolution in many years.......2000-05-19

Why does the peacock grow that tail? Why does the springbok leap straight up into the air when it sees a predator? Why do people behave heroically? The handicap principle answers these questions, eloquently, simply and with an overwhelming sense of conviction. The peacock is advertising his fitness. He is saying to the female in essence, I am so fit I can carry around this cumbersome adornment and still scratch out a very fine living. The springbok is saying to the predator: don't even think about going after me. I am in such good shape I can waste energy jumping up and down and still have plenty of reserves to outrun you. Save us both the bother and go after someone weaker. (By the way, the springbok jumps straight up instead of sideways because by jumping straight up its performance can be effectively judged by a predator from any direction.) And the man who dives into the swiftly flowing river to save a drowning child is actually advertising his fitness and improving his station in society. He is so fit he can take chances that others dare not. He's the man the women want to mate with.

The Handicap Principle thus is about signals, signals between prey and predator, between one sex and the other, and between the individual and the group. The purpose of these signals is to display in an unequivocal way the fitness of the signaler. Note that such signals have to be "fake proof." They have to be what the authors call "reliable." An animal that can't run fast and has limited resources of energy can't waste them jumping in the air. It needs to get going immediately or to stay hidden if it is to have any chance of survival. A man leads with his chin. That's a signal that he's confident. When men had beards it was a little dangerous to stick your chin out since the other guy might grab your beard and you could be in trouble. People demonstrate wealth by wasting money. This is a "reliable" (if ugly) signal because without an ample supply of money, you can't afford to waste it.

Part of the beauty of this book comes from the personality of the authors, who spent a large part of their lives studying little babbler birds in Israel. I feel I know these little social birds just from the loving descriptions in the text. One can see that even though the Zahavis made their discovery of the handicap principle in 1975 and waited almost two decades before it was generally accepted in the scientific community, they harbor no bitterness, nor is their tone at all gloating. They come across as hard-working field scientists who love their work and nature.

Besides being full of exciting and original ideas, The Handicap Principle is also extremely well written. Each sentence is clear and to the point without the burden of unnecessary jargon or the wordy clumsiness sometimes found in such books. Amotz and Avishag Zahavi took great pride in effectively communicating their ideas to a wide audience. Additionally there are scores of exquisite, loving little black and white drawings by illustrator Amir Balaban of animals, birds, insects and people, etc., illuminating the text.

If you're interested in evolutionary theory, this is a book not to be missed. As Jared Diamond says on the cover, "Read this fine book, and discover what the excitement is all about."

I loved it, insightful, entertaining, astounding........1998-05-06

This very readable book covers a wide range of biological behavior, and really demonstrates the reality of the Handicap Principle. Not only am I convinced of its truth, but now understand much more about human behavior than before.

Average customer rating:

short and to the point!

Principles of Developmental Biology
Fred H. Wilt , and Sarah Hake
Manufacturer: W. W. Norton & Company
ProductGroup: Book
Binding: Hardcover

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ASIN: 0393974308

Book Description

Fred Wilt and Sarah Hake's Principles of Developmental Biology is a modern new text for the undergraduate course in developmental biology, informed by the molecular and cell biology revolutions that have changed the field over the last fifteen years. Designed for the one-semester undergraduate course, Principles of Developmental Biology stresses fundamental concepts, a select number of instructive experiments and cases, and contemporary research in its historical context.

Customer Reviews:

short and to the point!.......2004-05-07

This is a great textbook for developmental biology students, or for people looking for general information on the subject! The text contains background "boxes" with information on genetics and biochemistry so you dont really need background knowledge in those subjects to understand the content of the book. It is short, so it doesn't go into too much detail but there's enough information to understand the concepts! This text is not like most texts where they are so boring and hard to read that you just give up. It's fairly easy reading and keeps things interesting enough to read the assigned pages.

Biology of Aging: Observations & Principles

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Biology of Aging: Observations & Principles
WOW!

Biology of Aging: Observations & Principles
Robert Arking
Manufacturer: Sinauer Associates
ProductGroup: Book
Binding: Hardcover

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ASIN: 0878930434

Book Description

The Second Edition of Biology of Aging: Observations and Principles is a complete, class-tested overview of the biological processes underlying aging at the molecular, cellular, organismal, and population levels, presented in a comparative and evolutionary context. The thrust of the book is to answer the question as to why and how we age. Rather than simply interpreting aging in the traditional health/disease context, the text describes and analyzes human aging within a strong biological and evolutionary context. It treats information on populations thoroughly (although not mathematically) to differentiate between aging and non-aging populations and to familiarize the reader with the demographic data underlying aging fact and theory, and delves into the links between aging and disease.

Biology of Aging neither perpetuates an artificial distinction between normal and pathological aging changes, nor is it merely a text on geriatrics. The author views aging as the eventual failure under stress of the body's repair systems, which leads to his view of disease as systemic failures that highlight weak points in the evolved anatomical and physiological design of the organism. The focus is on the basic biology of the aging process; diseases are merely one of the probes we use to explore the implications of that process. In addition, the book compares the intrinsic and extrinsic factors that regulate aging in terms of what is known and what is hypothesized, delineates the differences between the two, outlines practical and safe methods to partially modulate aging that are available to the reader, and follows a flexible format that fits a variety of course requirements and instructors' preferences without losing continuity.

Part One of the book provides factual and theoretical explanations of the aging process, including a brief history of human aging. In the central section (Parts Two and Three), the author critically examines the evidence for and against a wide variety of common and esoteric aging mechanisms. There is an extensive discussion of genetic mechanisms in both humans and model systems. In the final section, the salient features of the multiple aging mechanisms are synthesized into understandable models, the same processes being examined from several different points of view. The book closes with a chapter relating biological processes to the social environment and discusses the impact of changes in longevity on the social structure of our society.

A wealth of visual and tabular information facilitates the student's understanding of the phenomenon of aging. Figures and tables directly reflect the subject matter offered in the text, and the extensive bibliography, with references up to and including 1998, allows readers to easily research their particular interests.

Although intended as a textbook of gerontology for advanced undergraduates and beginning graduate students in biological or biomedical fields, Biology of Aging: Observations and Principles can profitably be read by professionals in many areas and by interested readers who have some basic background in general biology.

Customer Reviews:

Biology of Aging: Observations & Principles.......2006-03-09

It was exactly the edition I needed for my Biology of Aging course. It was delievered on time by Amazon

WOW!.......2002-10-18

I got this book because I used to do work on the author's lab and I was amazed by the work they were pursuing there.
I have read other bio textbooks, but what strikes me most about this one is that if you really just want to read one, this one has got it all. It is a complete survey, of all that is known and being studied currently on the topic of aging. From how to study aging to the goals of society in aging to everything inbetween. From the stuff that works, to might works, to absolutely does not, this is an excellent overview of the field.

Principles of Animal Design: The Optimization and Symmorphosis Debate

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why not?

Principles of Animal Design: The Optimization and Symmorphosis Debate

Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0521586674

Book Description

This book discusses the controversial issue of whether animals are designed according to the same rules that engineers use in building machines, namely that materials and energy are used economically while attempting to achieve a high level of performance. There is considerable scientific controversy surrounding this question because, although there is much evidence suggesting that animals are indeed well designed, evolutionary biology tells us that animals are not "engineered" but result from evolution by natural selection. In this volume these highly controversial questions are debated by eminent experts on the basis of a wealth of evidence ranging from the molecular biology and biochemistry of enzyme systems through the study of bone and muscle to the design and function of integrated systems of energy supply and the nervous system. The authors have made a special effort to present the chapters in a form that is accessible to a broad readership of biologists interested in basic principles.

Customer Reviews:

why not?.......2001-04-20

This is a very exciting book about one of the most controversial and polemic topics in comparative physiology, morphology and evolutionary biology. If you are trying to find out answers about animal design and optimization, you must try this book. Controversial and challenging.

The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models (Developmental and Cell Biology Series)

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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models (Developmental and Cell Biology Series)
Charles J. Epstein
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Hardcover

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Book Description

This book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioural problems and malignancy. In The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models, Charles J. Epstein concerns himself with how and why a particular chromosome imbalance produces a specific phenotype. His fundamental goal is to connect chromosome aberrations with functional abnormalities in terms of gene expression, developmental and cell biology, and metabolism. Through his examination of this relationship, we learn more about normal development and function. The book begins with an exploration of several human autosomal aneuploid phenotypes, with particular emphasis on the relationship between genotype and phenotype. In the next part, broad theoretical considerations of the mechanisms which generate these phenotypes are examined with reference to studies on man and other organisms such as bacteria and mice. Experimental approaches to study the effects of aneuploidy are presented next with special attention paid to the development of model systems for studying human aneuploidy.

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Tell you the principles in a magic way!

Principles of Neural Development
Dale Purves , and Jeff W. Lichtman
Manufacturer: Sinauer Associates
ProductGroup: Book
Binding: Hardcover

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Development of the Nervous System, Second Edition

ASIN: 0878937447

Customer Reviews:

Tell you the principles in a magic way!.......2001-06-11

This book covered almost all the important topics in the field of developmental neurobiology, and they are arranged in a logic way, from general development to specific details, from simple functions to complicated ones, from systematic to cellular to molecular level. Then, in the end, they lead to the concise principles summarized by the authors. As for a new beginner in this magic field, this book supplies me with rich facts along the history of this developing science, as well as lots of inspirations. As for the professionals, this book is also worth reading as a excellent systematic review and a splendid panorama of the beautiful scenery in this field. There are several points about this book that impressed me deeply and lured me to read it time and time again that I want to list as below: 1) The book describes a lot of the classical experiments that have profoundly influenced the way this new science has developed. This is interesting, because it makes the dry principles juicy. Also the experiments form a kind of challenge for the reader, because you can always set yourself in the same situations as the brainy experimenters mentioned in the book, thinking and analyzing together with them and being for and against their views and conclusions. 2) Weaker voices from the opposite side in the heated historical discussions can also be heard in this book. This is of great significance, because the realistic record encourages you to discard the preconceptions and bravely stand out to doubt the deep-rooted theories and explanations. In fact, there are few sure things, and most are mysterious, which make science magic. 3) The tradition of a branch of science can never be ignored because, to a certain degree, it decides how this science will develop, to which direction it will go, and what the chief problems are that are of the greatest power to revolutionize the whole field. The book tells you the history, along the way it tells science. And it shows great respect to the legends in this realm of science by opening boxes in every chapter to focus your attention to their contributions and to their strong willing versus an arduous journey of research. 4) The authors¡¯ diligence can be sensed from every line of the book, and every point in the book is based on concrete facts accumulated from the authors¡¯ extensive reading and research. Every item of reference is listed along the text, so it is convenient for the reader to hunt the pith from the forest of scientific literature. The strict attitude of the authors makes the book able to stand the test of time. 5) There are a lot of diagrams in the book, which make the reading activity much faster and easy, and the images printed in the mind keep the memories vivid and clear. At the same time, the language of this book is easy to understand as well as accurate. In only three pages, it clarifies Hebel¡¯s theory of visual cortex, which won the Nobel¡¯s prize in the 1980s, and science should be made easier like this, right? By all means, you should not let the chance go to experience this magic journey. Read this friendly book, and make sense how the magic nervous system comes into life!

Evolutionary Principles of Human Adolescence (Lives in Context)

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Evolutionary Principles of Human Adolescence (Lives in Context)
Glenn Weisfeld
Manufacturer: Basic Books
ProductGroup: Book
Binding: Paperback

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ASIN: 0813333180

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