Principles of Neural Science

Book Description

Now in resplendent color, the new edition continues to define the latest in the scientific understanding of the brain, the nervous system, and human behavior. Each chapter is thoroughly revised and includes the impact of molecular biology in the mechanisms underlying developmental processes and in the pathogenesis of disease. Important features to this edition include a new chapter - Genes and Behavior; a complete updating of development of the nervous system; the genetic basis of neurological and psychiatric disease; cognitive neuroscience of perception, planning, action, motivation and memory; ion channel mechanisms; and much more.

Customer Reviews:

Beware of the digital upgrade.......2007-09-05

I wanted to forwarn other users, especially students, of the pitfalls of the digital upgrade option:

1) Don't buy the upgrade if you're hoping to get access to it through the library computers, instead of having to lug the massive book to school. Apparently, you cannot view any online book from more than 7 different computers within a 30 day period. And, consequently, if the cache happens to get cleared after each session (as is the case with most shared computers), then you're limited to only 7 sessions with ANY computer.

2) Beware that the book is hard to read online. It's great for adding annotations (highlighting text, adding bookmarks, typing notes, etc.), but it's a real strain on the eyes if you try to read a full chapter. The text is low contrast (gray on white) and low resolution. Even when you use the Zoom-in feature (which lets you increase the size a little bit), it's still hard on the eyes. The text is still just blurry enough to make you think you might need glasses. After several chapters, you probably will need glasses :-)

You can check the quality first by viewing the Preview. That's representative of the whole book. Try reading an entire page and decide for yourself. On the plus side, if you do buy the book, and realize that these issues really do pose a problem for you, Amazon lets you request a refund, as long as you have viewed less than 20% of the book. 20% of 1300 pages is a lot, so you should be fine.

From Start to End.......2007-03-28

This is a great educational text. Each chapter starts from cellular level and progresses to the functional and clinical level. Being a chiropractor and working with the spine everyday I need to understand exactly where the problem starts and not focus on the symptoms. This text has allowed me to understand what is neurophysiologically going on with my patients and improve their course of treatment. As described the neurological system is the electricity of the body and if a fuse decides to blow you need to know where to look.

Impressive for a textbook.......2007-02-13

As far as textbooks go, this has to be one of the best that I have come across...and I have come across quite a few. The material is divided into closely related sections, and the text is clear and to the point in its explanation. Not much filler text or needless material. The diagrams are pretty clear and well positioned in the sections also.

Great Reference Book.......2007-01-06

The text is extremely clear and to the point. The diagrams are also simple to understand. Every major topic in neurosci is discussed, allowing you to get an excellent foundation such that you could read any recent publications on that topic and understand completely what the authors are referring to.

A Masterful Medical Book of Great Importance Written by a Nobel Laureate!.......2006-06-07

I am a Female Reconstructive Surgeon who while reading a diversified field of topics have fallen very fond of a particular work. This is Principles of Neural Science. having just completed the 2000 edition I can guarrantee that the new edition due June 2006 will be even more captivatiing. If you have the opportunity to see Dr Kandel speak please do he is an academic historian who gives a broad history of each critical piece of medical history to each of his topics. But returning to his epic, Principles of Neural Science is akin to Newtons Principia in that is a sublime masterpiece. The Kandell prose is colorful, smooth and insightful for medical science. I have found it easy to read 100-200 pages a day so that the 1400 page book took only a week to discover. The illustrations are the best for any field of Medicine and I have read alll the classics- Harrisions & Cecils Medicine and Schwartz and Sabistons General Surgery neither of these books elucidates the subjugate field with this type of clarity and instructional prose. Do as I have done and preorder the new edition. Those with any interest in the brain will certainly be amazed at the easy depth of information you will achieve. Believe me I am writing a book -Female Reconstructive Surgery and I will be implementing operative 17.2 million pixel photography to achieve the splendid vision the Kandel has produced with his illustrations. I have learned so much on how a book for Surgeons should be written from this Nobel Laureate

Flow Cytometry: Principles and Applications

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Flow Cytometry: Principles and Applications

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1588296911

Book Description

Flow cytometry forms an integral part of both basic biological research and clinical diagnosis in pathology. This straightforward new volume provides a clear, easy-to-read, and practical manual for both clinicians and non-clinicians at all levels of their careers. The chapter topics range from basic principles to more advanced subjects, such as apoptosis and cell sorting. Throughout Flow Cytometry: Principles and Applications, well-informed expert contributors present theoretical descriptions and practical protocols on this important and complex laboratory technique and its applications. Immunologists and Hematologists in the field of pathology, as well as biological researchers working with both human and animal models will appreciate the simple, clear-cut style in which principles and protocols in this volume are presented, and will refer to this book time and time again for clear and easy-to-follow protocols.

Sickle Cell Disease: Basic Principles and Clinical Practice

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Sickle Cell Disease: Basic Principles and Clinical Practice
Stephen H. Embury , and Robert P. Hebbel
Manufacturer: Lippincott Williams & Wilkins
ProductGroup: Book
Binding: Hardcover

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Book Description

Written by 80 of the world's foremost basic scientists and clinicians, this volume is the first comprehensive reference on sickle cell disease. Because this disease has diverse manifestations and involves many medical specialties, the contributors were chosen for their expertise in specific areas. Their discussions cover virtually every aspect of the disease--its molecular and cellular biology, pathophysiology, diagnosis, organ-specific complications, and clinical management. Coverage begins with recent laboratory findings on sickle hemoglobin and sickle red cell pathology. Subsequent sections examine the pathophysiology and natural history of sickle cell disease and describe diagnostic methods, including prenatal diagnosis and neonatal screening. A major section focuses on strategies for management of the organ-specific complications and psychosocial aspects of the disease. Coverage of therapy includes antibiotics, transfusion, surgery, pain control, nursing concerns, and future prospects for cure of the disease by gene therapy, bone marrow transplantation, and drugs that induce fetal hemoglobin synthesis.

Cell Chemistry and Physiology: Part IV (Principles of Medical Biology)

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Good way to cell chemistry

Cell Chemistry and Physiology: Part IV (Principles of Medical Biology)

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

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Book Description

This volume is intended to complete the Cell Chemistry and physiology module. It is about how the traditional boundaries of cell chemistry and physiology are being erased by molecular biology. We do not think it necessary to elaborate on this theme, particularly since the body of core knowledge found in this volume brings us a stage closer to answering the question, "what makes cell biology into a new discipline?"
The first part of the volume deals with the chemistry of actin and myosin and is followed by chapters on cell motility, ATP synthesis in muscle, and contraction in smooth and skeletal muscle. Here the reader is immediately made aware of the contributions molecular biology is making to our understanding of the molecular mechanisms underlying muscle contraction. It is perhaps enough to point out that Huxley's concept of the cross-bridge cycle and generation of force can now be explained in molecular terms. Topics such as muscle fatigue and muscle disorders, as well as malignant hyperthermia are bound to arouse active learning in the student and set the stage for problem-based learning.
Most medical students look askance at thermobiology. We think this is a mistake; hence, we have included a section dealing with this subject. This brings us to the chapter on the heat shock response, which at the very outset makes clear that many stressors besides heat are known to result in heat shock gene expression. Many of the heat shock proteins occur in unstressed cells and some of them behave as chaperones. These proteins also reach high levels in a wide range of diseases including neurodegenerative disorders. Whether certain diseases are the result of mutations in the heat shock genes is not yet known. As will be appreciated, much of the work done in this field involved the use of cultured cells. Animal cells in culture are the subject of the last chapter.

Customer Reviews:

Good way to cell chemistry.......2003-01-28

This book has some good title and context about ion transport across the cell membrane. Understanding of ions transport is very essentail way to study of cell membrane functions and its responses to stimuli. It is very good for any biological and medical students that have well known information about ionic events in and out of the cell. Some students don't suppose how ions act and transport across the cytoplasmic membranes. This book make better idea for ions function and ionic behavior in cells. Chapers of the book have well arrangement and good figures. I recommend it for study.

Glial Cell Development: Basic Principles and Clinical Relevance

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Glial Cell Development: Basic Principles and Clinical Relevance

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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Book Description

This is a new edition in the Cellular and Molecular Neurobiology series. The vast majority of cells in the nervous system are glial cells. During development, these cells provide growth factors that stimulate the proliferation, migration and survival of neurones and their precursors, and promote and guide axonal growth. In the mature nervous system, glial cells provide insulating myelin sheathe around axons and provide metabolic and structural support for neurones. Glial cells also have a major influence on the local response to injury of the central nerve tract and the peripheral nervous system, either promoting, or inhibiting, axonal regrowth and recovery of lost function. This book provides a comprehensive, state-of-the-art overview of research into the development, function and malfunction of glial cells. It offers a compelling insight into how basic research throws light onto diseases and disorders and points the way towards treatments. Teams of internationally renowned experts, all active in research, have contributed chapters.

Cellular Organelles and the Extracellular Matrix (Principles of Medical Biology)

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Cellular Organelles and the Extracellular Matrix (Principles of Medical Biology)

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

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ASIN: 1559388048

Book Description

This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these disorders. As an example, mutations in the genes encoding integral membrane proteins are found to lead to disturbances in peroxisome assembly. It is also interesting and significant that mistargeting of protein is now thought to be another cause. It will be revealing to see whether mistargeting is the result of mutations in the genes encoding chaperones.
The second part of the volume is concerned with the extracellular matrix. It sets out to show that a vast body of new knowledge of the extracellular matrix is available to us. Take for example the integrin family of cell adhesion receptors. It turns out that integrins play a key role not only in adhesion but also in coupling signals to the nucleus via the cytoskeleton. As for fibronectins, they seem to link the matrix with the cytoskeleton by interacting with integrins.
Collagen molecules are dealt with in the last two chapters. The boundaries of collagen in disease are defined by drawing a clear line of demarcation between systemic connective tissue disorders (e.g., scleroderma), better known as autoimmune diseases, and the heritable, and the heritable diseases such as osteogenesis imperfect and the Marfan syndrome. This classification takes into account a second group of acquired disorders of collagen forming tissues in which regional fibrosis is the hallmark. Liver cirrhosis and pulmonary fibrosis are prime examples.
The decision to place Volumes 2 and 3 before those dealing with cell chemistry was not easily made. It was based on the view that most students will have had an undergraduate course in biochemistry of cell biology or both courses, and that they could go to Volumes 4-7 in which the subject of cell chemistry is covered, and then return to Volumes 2 and 3.

Principles of Cell and Molecular Biology (2nd Edition)

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Brilliant, Indispensable!!
One of the useful books for beginner

Principles of Cell and Molecular Biology (2nd Edition)
Lewis J. Kleinsmith , and Valerie M. Kish
Manufacturer: Benjamin-Cummings Publishing Company
ProductGroup: Book
Binding: Hardcover

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ASIN: 0065004043

Customer Reviews:

Brilliant, Indispensable!!.......1999-01-01

This was, by far, the best textbook in my entire undergraduate education. The book was used for my Cell Biology class at SFSU, but I referred to it endless times during subsequent courses where the required texts just couldn't help. I used this book as a supplement for: General Microbiology, Immunology, Genetics, and Microbial Physiology. Buy this book!

One of the useful books for beginner.......1998-10-26

Dr. Kleinsmith used to be my teacher at the University of Michigan. He taught me Biology of Cancer. The way he taught was excellent and this book of his really represents his talent in teaching. For those who do not have solid background in cell and molecular biology but want to learn more about it, this book is specially written for you. The material presented here, though not advanced, covers everything needed as a prerequisite for higher level biology. It is worth reading. I am sure that after you finish one chapter in this text, you will feel yourself know some biology better. Try it for yourself.

Advances in Molecular and Cell Biology: Principles of Sex-Based Differences in Physiology (Advances in Molecular and Cell Biology)

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Advances in Molecular and Cell Biology: Principles of Sex-Based Differences in Physiology (Advances in Molecular and Cell Biology)

Manufacturer: Elsevier Science & Technology
ProductGroup: Book
Binding: Hardcover

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ASIN: 044451497X

Cell Injury (Principles of Medical Biology)

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Cell Injury (Principles of Medical Biology)

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

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ASIN: 1559388188

Book Description

At no time since the introduction of cell pathology by Virchov more than a century ago has the outlook for pathology as an integrated discipline been brighter. It is surely clear that the revolution of molecular biology and biotechnology has wrought profound changes in the various basic medical sciences including pathology. But to say this is hardly enough, particularly since the burgeoning field of molecular pathology has been challenged and altered by a powerful concept, namely, programmed cell death. Called apoptosis, which in Greek means falling off, it is intimately connected with cell removal and regeneration; that is, with tissue homeostasis. Nowhere is this more dramatically illustrated as a physiological process than in the gut, endometrium, and embryo. Similarly, little doubt is left that clusters of apoptotic-induced genes are involved in the control of carcinogenesis. The evidence for this is already compelling; it is plain, for instance, that p53 triggers apoptosis whenever DNA repair is incomplete. The question now is, how quickly can the Genome project shed some light on the genetics underlying apoptosis?
It is tolerably clear that there is no such thing as a general model of cell injury, but there are models, as it should be. One thing is already certain: cell stress during septicemia is the quintessential model. Death here requires the failure of at least three organs! We are told that oxidative stress plays a major role in the pathogenesis of the syndrome. This is not surprising. The whole subject of reactive oxygen species (ROS) is thus given much weight. By far, the most important mechanisms underlying membrane lesions, due to ROS, are those involving inactivation of several key enzymes among a host of enzymes, lipid peroxidation, and iron speeding up bydroxyl radical production. The stark fact is that evolutionary pressure has produced a fiasco by not endowing the cell with enough antioxidant power or reducing the ROS pool. In organs with high O2 consumption, mitochondrial leakage of O2 (the superoxide anion) could well be considerable. Thus our main point here is that caloric restriction gives us a way of tackling the problem for the time being. One has only to remember that it improves survival.
Whether there has been a "breakthrough" is not yet quite certain, but oxidative stress combined with long-term overactivation of glutamate receptors may enable us to understand several neurodegenerative disorders including Parkinson's disease. This broad topic is touched upon in detail in the Neurobiology module (Volume 14).
There is a vast literature relating to injury of heart muscle. Two chapters address this topic. Looking back, are we to conclude that a membrane lesion, which is essentially functional, does not exist? Consider, as an example, the NMR experiments in which a raised Pco2, leads very rapidly to a fall in heart muscle pH. We also venture whether it begs several fundamental questions relating to events that precede the onset of necrobiosis. A telling argument is that an early event could be as simple as the root of the problem in ischemia is not as simple as that of a leaky membrane. But the initiating event would seem to be a redox imbalance vix., changes in cytosolic and mitochondrial NAD+/NADH.
We urge the student to go back to Volume 4 (Part II) and read, once more, the chapter on Cellular ATP by Harris. In Part IV, the chapter on the Human Heat Shock Response by Jurivich merits a second reading. Though the present volume is a veritable source of many unanswered questions, it has the distinct simplicity of telling us that molecular pathology, like molecular biology, represents a way of thinking.

Cells: Principles of Molecular Structure and Function (Jones and Bartlett Series in Biology)

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Cells: Principles of Molecular Structure and Function (Jones and Bartlett Series in Biology)
David M. Prescott
Manufacturer: Jones & Bartlett Publishers
ProductGroup: Book
Binding: Hardcover

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